Results 31 to 40 of about 98,011 (316)

Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy

Skeletal Muscle, 2023
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction in slow muscle fibers.
Matthias R. Lambert, Emanuela Gussoni
doaj   +1 more source

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

eLife, 2023
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear.
Jonas R Knudsen, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen   +12 more
doaj   +1 more source

Needle muscle biopsy: technique validation and histological and histochemical methods for evaluating canine skeletal muscles

Semina: Ciências Agrárias, 2017
This study evaluated the needle muscle biopsy technique using a 6G Bergström percutaneous needle combined with histological and histochemical methods to analyze the skeletal muscle of dogs.
Sérgio de Almeida Braga, Felipe Gomes Ferreira Padilha, Ana Maria Reis Ferreira   +2 more
doaj   +1 more source

Investigating Passive Muscle Mechanics With Biaxial Stretch

Frontiers in Physiology, 2020
IntroductionThe passive stiffness of skeletal muscle can drastically affect muscle function in vivo, such as the case for fibrotic tissue or patients with cerebral palsy.
Benjamin B. Wheatley
doaj   +1 more source

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle.

, 1996
The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was
Shrimpton, C., Kendrick-Jones, J., Irving, M., Sleep, J., John Kendrick-jones, Ling, N., Carolyn Shrimpton, Ling, Nicholas, Malcolm Irvingt, Nicholas Ling, John Sleep   +10 more
core   +1 more source

Function of mTOR complex 1 and 2 in skeletal muscle [PDF]

, 2009
Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core   +1 more source

CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism

The Journal of Clinical Investigation, 2023
Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic properties. Fiber-type
Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova, Danielle A. Springer, Ioannis Papazoglou, Patricia M. Zerfas, Monica C. Skarulis, Alexandra C. McPherron, Sushil G. Rane   +10 more
doaj   +1 more source

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo [PDF]

, 2015
The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is abundantly expressed in trained muscles and regulates muscle adaptation to endurance exercise. Inversely, mice lacking a functional PGC-1α allele in muscle exhibit reduced muscle
Handschin, Christoph, Christoph Handschin, Regula Furrer, Furrer, Regula, Eisele, Petra Sabine, Markus Beer, Beer, Markus, Petra Sabine Eisele   +7 more
core   +1 more source

Influence of skeletal muscle heterogeneity on autophagic signaling and response

Autophagy Reports
Skeletal muscle is a heterogeneous tissue composed of fibers with distinct contractile, metabolic, and molecular characteristics. This intrinsic heterogeneity influences how individual fibers respond to physiological stimuli, pathological stress, and ...
Fasih A. Rahman, Joe Quadrilatero
doaj   +1 more source

FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension

BMC Musculoskeletal Disorders, 2007
Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave, Breur Gert, Olsen Aaron, Eash John, Hannon Kevin   +4 more
doaj   +1 more source