Results 31 to 40 of about 1,375,049 (303)

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. [PDF]

, 2007
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a key integrator of neuromuscular activity in skeletal muscle.
Handschin, Christoph, Li, P., Handschin, C., Lebrasseur, N. K., Li, Ping, Spiegelman, Bruce M, Maratos-Flier, E., Lebrasseur, Nathan K, Liu, Fenfen, Chin, Sherry, Maratos-Flier, Eleftheria, Spiegelman, B. M., Yan, Zhen, Yan, Z., Chin, S., Liu, F.   +15 more
core   +1 more source

Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy

Skeletal Muscle, 2023
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction in slow muscle fibers.
Matthias R. Lambert, Emanuela Gussoni
doaj   +1 more source

Needle muscle biopsy: technique validation and histological and histochemical methods for evaluating canine skeletal muscles

Semina: Ciências Agrárias, 2017
This study evaluated the needle muscle biopsy technique using a 6G Bergström percutaneous needle combined with histological and histochemical methods to analyze the skeletal muscle of dogs.
Sérgio de Almeida Braga, Felipe Gomes Ferreira Padilha, Ana Maria Reis Ferreira   +2 more
doaj   +1 more source

Influence of skeletal muscle heterogeneity on autophagic signaling and response

Autophagy Reports
Skeletal muscle is a heterogeneous tissue composed of fibers with distinct contractile, metabolic, and molecular characteristics. This intrinsic heterogeneity influences how individual fibers respond to physiological stimuli, pathological stress, and ...
Fasih A. Rahman, Joe Quadrilatero
doaj   +1 more source

CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism

The Journal of Clinical Investigation, 2023
Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic properties. Fiber-type
Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova, Danielle A. Springer, Ioannis Papazoglou, Patricia M. Zerfas, Monica C. Skarulis, Alexandra C. McPherron, Sushil G. Rane   +10 more
doaj   +1 more source

Investigating Passive Muscle Mechanics With Biaxial Stretch

Frontiers in Physiology, 2020
IntroductionThe passive stiffness of skeletal muscle can drastically affect muscle function in vivo, such as the case for fibrotic tissue or patients with cerebral palsy.
Benjamin B. Wheatley
doaj   +1 more source

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

eLife, 2023
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear.
Jonas R Knudsen, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen   +12 more
doaj   +1 more source

FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension

BMC Musculoskeletal Disorders, 2007
Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave, Breur Gert, Olsen Aaron, Eash John, Hannon Kevin   +4 more
doaj   +1 more source

Action potential-evoked calcium release is impaired in single skeletal muscle fibers from heart failure patients. [PDF]

PLoS ONE, 2014
Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to ...
Marino DiFranco, Marbella Quiñonez, Perry Shieh, Gregg C Fonarow, Daniel Cruz, Mario C Deng, Julio L Vergara, Holly R Middlekauff   +7 more
doaj   +1 more source

PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior [PDF]

, 2014
The benefits of exercise on wellbeing have been known to mankind for thousands of years, yet the underlying mechanisms of exercise have been explained only relatively recently.
Dinulović, Ivana
core   +1 more source