Chemical Relaxation of a Binary Mechanical Model System [PDF]
, 2022 With potential relevance to biomechanics, an interesting problem in statistical mechanics not previously solved is a binary mechanical model system. Discrete chemical states of proteins are often associated with discrete metastable structural states, such that with a change in state a protein acts as a molecular switch.
arxiv +1 more source
Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. [PDF]
PLoS ONE, 2014 Smooth muscle cells are maintained in a differentiated state in the vessel wall, but can be modulated to a synthetic phenotype following injury. Smooth muscle phenotypic modulation is thought to play an important role in the pathology of vascular ...
Feng Shi +4 more
doaj +1 more source
hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding. [PDF]
, 2013 This work builds upon our findings that proteins secreted by hESCs exhibit pro-regenerative activity, and determines that hESC-conditioned medium robustly enhances the proliferation of both muscle and neural progenitor cells.
CONBOY, Irina M +7 more
core +2 more sources
, 2014 The impacts of accelerated pH decline combined with high muscle temperature on post-mortem muscle metabolism and subsequent meat quality attributes have been extensively studied. Traditionally, this phenomenon has been observed in pork muscles, primarily
Y. H. Kim, R. Warner, K. Rosenvold
semanticscholar +1 more source
Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. [PDF]
PLoS ONE, 2011 Determining the sub-cellular localization of a protein within a cell is often an essential step towards understanding its function. In Caenorhabditis elegans, the relatively large size of the body wall muscle cells and the exquisite organization of their
Barbara Meissner +8 more
doaj +1 more source
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
core +1 more source
Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Physiological Reviews, 2019 Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which require costly hospitalization and extended rehabilitation.
L. Larsson +7 more
semanticscholar +1 more source
Mechanics, Energetics, Entropy and Kinetics of a Binary Mechanical Model System [PDF]
, 2022 With the formal construction of a thermodynamic spring, I describe the mechanics, energetics, entropy, and kinetics of a binary mechanical model system. A protein that transitions between two metastable structural states behaves as a molecular switch, and an ensemble of molecular switches that displace compliant elements equilibrated with a system ...
arxiv +1 more source
Phosphorylation of Subunit Proteins of Intermediate Filaments from Chicken Muscle and Nonmuscle Cells [PDF]
, 1979 The phosphorylation of the subunit proteins of intermediate (10-nm) filaments has been investigated in chicken muscle and nonmuscle cells by using a two-dimensional gel electrophoresis system. Desmin, the 50,000-dalton subunit protein of the intermediate
Balzer, David R., Jr. +2 more
core +1 more source
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]
G. Celli\`ere, D Menshykau and Dagmar Iber (2012) Biology Open 1,
775-788, 2012 Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature. Lung branching morphogenesis is strongly stereotyped and involves the recursive use of only three modes of branching.
arxiv +1 more source