Injectable scaffold materials differ in their cell instructive effects on primary human myoblasts
Journal of Tissue Engineering, 2017 Scaffolds are materials used for delivery of cells for regeneration of tissues. They support three-dimensional organization and improve cell survival.
Eva Kildall Hejbøl +3 more
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Modulation of caspase activity regulates skeletal muscle regeneration and function in response to vasopressin and tumor necrosis factor. [PDF]
PLoS ONE, 2009 Muscle homeostasis involves de novo myogenesis, as observed in conditions of acute or chronic muscle damage. Tumor Necrosis Factor (TNF) triggers skeletal muscle wasting in several pathological conditions and inhibits muscle regeneration.
Viviana Moresi +9 more
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Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]
, 2011 Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry +4 more
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A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]
, 2016 Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena +5 more
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Non-coding RNAs in skeletal muscle regeneration
Non-coding RNA Research, 2017 Following injury, skeletal muscles can regenerate from muscle specific stem cells, called satellite cells. Quiescent in uninjured muscles, satellite cells become activated, proliferate and differentiate into myotubes. Muscle regeneration occurs following
Tristan J.M. Gonçalves +1 more
doaj +1 more source
Genomic profiling reveals that transient adipogenic activation is a hallmark of mouse models of skeletal muscle regeneration. [PDF]
PLoS ONE, 2013 The marbling of skeletal muscle by ectopic adipose tissue is a hallmark of many muscle diseases, including sarcopenia and muscular dystrophies, and generally associates with impaired muscle regeneration. Although the etiology and the molecular mechanisms
Laura Lukjanenko +4 more
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Frontiers in Cell and Developmental Biology, 2022 Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD+, but little is known about their contribution to endogenous NAD+ turnover and muscle plasticity during skeletal muscle growth and remodeling.
Tanja Sonntag +15 more
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Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. [PDF]
, 2016 In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates
Barton, Elisabeth R +7 more
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EZH1 as a key mediator of exercise-induced H3K27me3 and H3K4me3 in mouse skeletal muscle
Advanced Exercise and Health ScienceEpigenetic modification is a key mechanism that enhances the response of skeletal muscle to exercise training. Exercise-induced H3K27me3, which is co-modified with H3K4me3, is crucial for gene responses and adaptation in skeletal muscle; however, how ...
Junya Shimizu +3 more
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Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration. [PDF]
PLoS ONE, 2015 When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs.
Yosuke Hiramuki +4 more
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