Results 41 to 50 of about 1,366,391 (310)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

: Role of Cripto in skeletal muscle regeneration

, 2012
International audienceSkeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here,
Iaconis, S., Guardiola, Ombretta, Brunelli, Silvia, Shen, Michael, M., Touvier, Thierry, Lonardo, Enza, Iaconis, Salvatore, Cossu, Giulio, Bouche, A., Liguori, Giovanna L., Liguori, Giovanna,, Lafuste, Peggy, Shen, M., Mourikis, Philippos, Bouché, Ann, Guardiola, O., Minchiotti, Gabriella, Liguori, G., Carmeliet, Peter, Andolfi, G., Tajbakhsh, S., Minchiotti, G., de Bock, Katrien, Andolfi, Gennaro, Brunelli, S., Shen, Michael M., de Bock, K., Mourikis, P., Lonardo, E., Lafuste, P., Liguori, Giovanna, L., Shen, Michael,, Tajbakhsh, Shahragim, Touvier, T., Cossu, G., Carmeliet, P.   +35 more
core   +1 more source

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Frontiers in Cell and Developmental Biology, 2022
Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD+, but little is known about their contribution to endogenous NAD+ turnover and muscle plasticity during skeletal muscle growth and remodeling.
Tanja Sonntag, Tanja Sonntag, Sara Ancel, Sara Ancel, Sonia Karaz, Paulina Cichosz, Guillaume Jacot, Maria Pilar Giner, José Luis Sanchez-Garcia, Alice Pannérec, Sofia Moco, Vincenzo Sorrentino, Carles Cantó, Carles Cantó, Jérôme N. Feige, Jérôme N. Feige   +15 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The role of myostatin during postnatal myogenesis and sarcopenia [PDF]

, 2007
Myostatin, a TGF-β superfamily member, is a key negative regulator of embryonic and postnatal muscle growth. In order to further elucidate the role of myostatin during postnatal growth, several lines of investigation were undertaken in mice.
Siriett, Victoria Katherine
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Mitochondrial glycerol 3‐phosphate dehydrogenase promotes skeletal muscle regeneration

EMBO Molecular Medicine, 2018
While adult mammalian skeletal muscle is stable due to its post‐mitotic nature, muscle regeneration is still essential throughout life for maintaining functional fitness.
Xiufei Liu, Hua Qu, Yi Zheng, Qian Liao, Linlin Zhang, Xiaoyu Liao, Xin Xiong, Yuren Wang, Rui Zhang, Hui Wang, Qiang Tong, Zhenqi Liu, Hui Dong, Gangyi Yang, Zhiming Zhu, Jing Xu, Hongting Zheng   +16 more
doaj   +1 more source

Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential. [PDF]

PLoS ONE, 2018
Cancer cachexia is a severe, debilitating condition characterized by progressive body wasting associated with remarkable loss of skeletal muscle weight.
Shoya Inaba, Atsushi Hinohara, Masashi Tachibana, Kazutake Tsujikawa, So-Ichiro Fukada   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source