Results 21 to 30 of about 2,447,481 (262)
Nature Communications, 2021 Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2, Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue regeneration in vivo.
Chao Wang +14 more
semanticscholar +1 more source
Chromatin Landscape During Skeletal Muscle Differentiation
Frontiers in Genetics, 2020 Cellular commitment and differentiation involve highly coordinated mechanisms by which tissue-specific genes are activated while others are repressed. These mechanisms rely on the activity of specific transcription factors, chromatin remodeling enzymes ...
Oscar Hernández-Hernández +2 more
doaj +1 more source
Skeletal muscle regeneration with robotic actuation–mediated clearance of neutrophils
Science Translational Medicine, 2021 Description Controlled cyclic loading with a robotic system accelerates muscle regeneration in mice by early removal of neutrophils and their chemical cues.
B. R. Seo +12 more
semanticscholar +1 more source
SCSMRD: A database for single-cell skeletal muscle regeneration
Journal of Integrative Agriculture, 2023 Skeletal muscle regeneration is a complex process where various cell types and cytokines are involved. Single-cell RNA-sequencing (scRNA-seq) provides the opportunity to deconvolute heterogeneous tissue into individual cells based on their transcriptomic
Xi-kang FENG +4 more
doaj +1 more source
Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration
Inflammation and Regeneration, 2022 Skeletal muscles have an extraordinary capacity to regenerate themselves when injured. Skeletal muscle stem cells, called satellite cells, play a central role in muscle regeneration via three major steps: activation, proliferation, and differentiation ...
H. Koike, I. Manabe, Y. Oishi
semanticscholar +1 more source
Decellularized Tissue for Muscle Regeneration [PDF]
International Journal of Molecular Sciences, 2018 Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure ...
Urciuolo A., De Coppi P.
openaire +3 more sources
Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy
Frontiers in Cell and Developmental Biology, 2020 The ubiquitin–proteasome system has the capacity to degrade polyubiquitinated proteins and plays an important role in many cellular processes. However, the role of Rpt3, a crucial proteasomal gene, has not been investigated in adult muscles in vivo ...
Yasuo Kitajima +10 more
doaj +1 more source
Stem Cells International, 2021 The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem cell fate determination and muscle regeneration are still not fully understood ...
Yu Liang +7 more
doaj +1 more source
FOS licenses early events in stem cell activation driving skeletal muscle regeneration
Cell Reports, 2021 SUMMARY Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle. Although SCs have been investigated for nearly 60 years, the molecular drivers that transform quiescent SCs into the rapidly ...
A. E. Almada +10 more
semanticscholar +1 more source
Nucleic Acids Research, 2022 Long noncoding RNAs (lncRNAs) play important roles in the spatial and temporal regulation of muscle development and regeneration. Nevertheless, the determination of their biological functions and mechanisms underlying muscle regeneration remains ...
Wei Lv +16 more
semanticscholar +1 more source