Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]
, 2012 BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo +2 more
core +1 more source
Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration
Frontiers in Cell and Developmental Biology, 2020 Adult skeletal muscle has a remarkable ability to regenerate. Regeneration of mature muscle fibers is dependent on muscle stem cells called satellite cells.
Yuki Yoshimoto +4 more
doaj +1 more source
Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]
, 2015 Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P. +6 more
core +1 more source
Macrophage-released ADAMTS1 promotes muscle stem cell activation. [PDF]
, 2017 Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular ...
Aggarwal, Abhishek +7 more
core +2 more sources
Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration
Advanced Science, 2023 It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigger muscle ...
Lanfang Luo +14 more
doaj +1 more source
Skeletal muscle regeneration is modulated by inflammation
Journal of Orthopaedic Translation, 2018 Skeletal muscle regeneration is a complex process orchestrated by multiple steps. Recent findings indicate that inflammatory responses could play central roles in bridging initial muscle injury responses and timely muscle injury reparation.
Wenjun Yang, Ping Hu
doaj +1 more source
Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core +3 more sources
Cells, 2021 Background: Skeletal muscle is one of the only mammalian tissues capable of rapid and efficient regeneration after trauma or in pathological conditions.
Matthew Borok +6 more
doaj +1 more source
Non Muscle Stem Cells and Muscle Regeneration [PDF]
, 2008 Skeletal muscle of the vertebrate embryo originates from paraxial mesoderm (somites, somitomers and prechordal cephalic mesoderm) (Christ and Ordahl 1995) and is formed in discrete steps by different classes of myogenic progenitor cells (Cossu and Biressi 2005).
G. Messina, S. Biressi, G. Cossu
openaire +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background The progressive deterioration of tissue–tissue crosstalk with aging causes a striking impairment of tissue homeostasis and functionality, particularly in the musculoskeletal system.
Belle Yu‐Hsuan Wang +5 more
doaj +1 more source