Results 11 to 20 of about 2,447,481 (262)

Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review

Inflammation and Regeneration, 2023
The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the coordinated activities of multiple cell types and biomolecular factors.
Khurshid Ahmad, Sibhghatulla Shaikh, H. Chun, Shahid Ali, J. Lim, Syed Sayeed Ahmad, E. Lee, I. Choi   +7 more
semanticscholar   +1 more source

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis

Journal of Cachexia, Sarcopenia and Muscle, 2021
Satellite cells (SCs) are critical to skeletal muscle regeneration. Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle‐specific deletion of Tfr1 results in growth ...
Hongrong Ding, Shujie Chen, Xiaohan Pan, Xiaoshuang Dai, Guihua Pan, Ze Li, Xudong Mai, Ye Tian, Susu Zhang, Bingdong Liu, Guangchao Cao, Zhicheng Yao, Xiangping Yao, Liang Gao, Li Yang, Xiaoyan Chen, Jia Sun, Hong Chen, Mulan Han, Yulong Yin, Guohuan Xu, Huijun Li, Weidong Wu, Zheng Chen, Jingchao Lin, Liping Xiang, Jun Hu, Yan Lu, Xiao Zhu, Liwei Xie   +29 more
semanticscholar   +1 more source

Autophagy in muscle regeneration: potential therapies for myopathies

Journal of Cachexia, Sarcopenia and Muscle, 2022
Autophagy classically functions as a physiological process to degrade cytoplasmic components, protein aggregates, and/or organelles, as a mechanism for nutrient breakdown, and as a regulator of cellular architecture.
Wei Chen, Yushi Chen, Yuxi Liu, Xinxia Wang   +3 more
semanticscholar   +1 more source

Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration

Nature Communications, 2022
Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive.
A. Nawaz, M. Bilal, S. Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, Koichi Tsuneyama, Ayumi Nishimura, Yasuhiro Nishida, S. Yamamoto, M. Sasahara, J. Imura, Hisashi Mori, M. Matzuk, F. Kudo, I. Manabe, A. Uezumi, T. Nakagawa, Y. Oishi, K. Tobe   +23 more
semanticscholar   +1 more source

A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy

Frontiers in Bioengineering and Biotechnology, 2021
Cerebral palsy is a neuromusculoskeletal disorder associated with muscle weakness, altered muscle architecture, and progressive musculoskeletal symptoms that worsen with age. Pathological changes at the level of the whole muscle have been shown; however,
Stephanie Khuu, Justin W. Fernandez, Justin W. Fernandez, Geoffrey G. Handsfield   +3 more
doaj   +1 more source

Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles

Nature Aging, 2021
Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore youthful features to aged tissues. However, the systemic mediators of those rejuvenating effects remain poorly defined.
A. Sahu, Zachary J. Clemens, S. Shinde, S. Sivakumar, Abish Pius, Ankit Bhatia, S. Picciolini, C. Carlomagno, A. Gualerzi, M. Bedoni, Bennett Van Houten, M. Lovalekar, N. Fitz, Iliya Lefterov, A. Barchowsky, R. Koldamova, F. Ambrosio   +16 more
semanticscholar   +1 more source

The Role of Mitochondria in Mediation of Skeletal Muscle Repair

Muscles, 2023
Musculoskeletal health is directly linked to independence and longevity, but disease and aging impairs muscle mass and health. Complete repair after a pathological or physiological muscle injury is critical for maintaining muscle function, yet muscle ...
Stephen E. Alway, Hector G. Paez, Christopher R. Pitzer   +2 more
doaj   +1 more source

Muscle cell-derived cytokines in skeletal muscle regeneration

The FEBS Journal, 2022
Regeneration of the mammalian adult skeletal muscle is a well‐orchestrated process regulated by multiple proteins and signalling pathways. Cytokines constitute a major class of regulators of skeletal myogenesis.
R. Waldemer-Streyer, Dongwook Kim, Jie Chen   +2 more
semanticscholar   +1 more source

A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues

Frontiers in Cell and Developmental Biology, 2020
Primary culture of skeletal muscle stem cells (MuSCs) is indispensable to study the dynamics of muscle regeneration and homeostasis. Here we describe the modified pre-plating method for isolating MuSCs in culture with greatly improved purity, yield, and ...
Kiyoshi Yoshioka, Yasuo Kitajima, Narihiro Okazaki, Ko Chiba, Akihiko Yonekura, Yusuke Ono   +5 more
doaj   +1 more source

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

Frontiers in Physiology, 2021
Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D.
C. M. Latham, Camille R. Brightwell, Alexander R Keeble, Brooke D. Munson, N. T. Thomas, Alyaa M. Zagzoog, C. Fry, J. L. Fry   +7 more
semanticscholar   +1 more source