Results 11 to 20 of about 305,195 (311)
Stem Cells International, 2021 The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem cell fate determination and muscle regeneration are still not fully understood ...
Yu Liang +7 more
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Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy
Frontiers in Cell and Developmental Biology, 2020 The ubiquitin–proteasome system has the capacity to degrade polyubiquitinated proteins and plays an important role in many cellular processes. However, the role of Rpt3, a crucial proteasomal gene, has not been investigated in adult muscles in vivo ...
Yasuo Kitajima +10 more
doaj +1 more source
The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]
, 2015 The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio +16 more
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Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]
, 2015 In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia +2 more
core +9 more sources
Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells
Stem Cell Research, 2015 Aside from its role in cell membrane integrity, cholesterol is a key component in steroid hormone production. The vital functions of steroid hormones such as estrogen, testosterone, glucocorticoids (Gcrts) and mineralocorticoids (Mnrts) in perinatal and ...
Joaquim Cabral-Teixeira +5 more
doaj +1 more source
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
Immunometabolism of macrophages regulates skeletal muscle regeneration
Frontiers in Cell and Developmental Biology, 2022 Sarcopenia is an age-related progressive loss of skeletal muscle mass, quality, and strength disease. In addition, sarcopenia is tightly correlated with age-associated pathologies, such as sarcopenic obesity and osteoporosis.
Yu-Fan Chen +9 more
doaj +1 more source
Pharmacological inhibition of PKCθ counteracts muscle disease in a mouse model of duchenne muscular dystrophy [PDF]
, 2017 Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a severe muscle disease caused by a mutation in the dystrophin gene. We previously showed that genetic ablation of Protein Kinase C θ (PKCθ) in mdx, the mouse
Benedetti, Anna +8 more
core +2 more sources
Decellularized Tissue for Muscle Regeneration [PDF]
International Journal of Molecular Sciences, 2018 Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure ...
Urciuolo A., De Coppi P.
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2023 Skeletal muscle has a highly regenerative capacity, but the detailed process is not fully understood. Several in vitro skeletal muscle regeneration models have been developed to elucidate this, all of which rely on specialized culture conditions that ...
Naoya Kase +4 more
doaj +1 more source