Results 31 to 40 of about 3,653 (216)
6mer seed toxicity in tumor suppressive microRNAs
Nature Communications, 2018 Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.
Quan Q. Gao +8 more
doaj +1 more source
Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity. [PDF]
PLoS ONE, 2017 Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited.
Hiroshi Sakai +10 more
doaj +1 more source
The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development
Frontiers in Aging Neuroscience, 2015 Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Julia eMeireles Nogueira +9 more
doaj +1 more source
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Nature Communications, 2017 Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging ...
Marco Segatto +16 more
doaj +1 more source
Preparation of Adult Mouse Muscle Stem Cells
Bio-Protocol, 2013 Muscle stem cells are adult stem cells responsible for muscle development, growth and regeneration. Current knowledge suggests those cells are heterogeneous population shared their position between the sarcolemma and basal lamina of muscle fibers.
Ju Li
doaj +1 more source
Cells, 2021 Background: Skeletal muscle is one of the only mammalian tissues capable of rapid and efficient regeneration after trauma or in pathological conditions.
Matthew Borok +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan +15 more
wiley +1 more source
Regulation of muscle stem cell fate
Cell Regeneration, 2022 AbstractSkeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation ...
Xin Fu, Cheng-le Zhuang, Ping Hu
openaire +3 more sources
Misperception of Body Weight After Childhood Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle +8 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source