Results 41 to 50 of about 481,133 (304)

Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

EMBO Molecular Medicine, 2017
Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical
Jeong‐A Lim, Lishu Li, Orian S Shirihai, Kyle M Trudeau, Rosa Puertollano, Nina Raben   +5 more
doaj   +1 more source

Specialized mouse embryonic stem cells for studying vascular development. [PDF]

, 2014
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B, Fan, Yuhong, Glaser, Drew E, Hatano, Rachel, McCloskey, Kara E, Medrzycki, Magdalena   +5 more
core   +1 more source

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity. [PDF]

PLoS ONE, 2017
Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell number is limited.
Hiroshi Sakai, Sumiaki Fukuda, Miki Nakamura, Akiyoshi Uezumi, Yu-Taro Noguchi, Takahiko Sato, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Shahragim Tajbakhsh, So-Ichiro Fukada   +10 more
doaj   +1 more source

Macrophage-released ADAMTS1 promotes muscle stem cell activation. [PDF]

, 2017
Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular ...
Aggarwal, Abhishek, Cho, Joonseok, Du, Hongqing, Feldman, Brian J, Mueller, Alisa A, Rando, Thomas A, Shih, Chung-Hsuan, Wosczyna, Michael N   +7 more
core   +2 more sources

A deep learning framework for denoising and ordering scRNA-seq data using adversarial autoencoder with dynamic batching

STAR Protocols
Summary: Single-cell RNA sequencing (scRNA-seq) provides high resolution of cell-to-cell variation in gene expression and offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms. However, technical challenges such as low
Kyung Dae Ko, Vittorio Sartorelli
doaj   +1 more source

New perspectives to repair a broken heart [PDF]

, 2009
The aim of cardiac cell therapy is to restore at least in part the functionality of the diseased or injured myocardium by the use of stem/ progenitor cells.
BARILE, Lucio, CHIMENTI, ISOTTA, DI CONSIGLIO, ALBERTO, FORTE, ELVIRA, FRATI, GIACOMO, GAETANI, ROBERTO, GIACOMELLO, Alessandro, IONTA, VITTORIA, MESSINA, ELISA, MIRALDI, Fabio   +9 more
core   +1 more source

A deep learning adversarial autoencoder with dynamic batching displays high performance in denoising and ordering scRNA-seq data

iScience
Summary: By providing high-resolution of cell-to-cell variation in gene expression, single-cell RNA sequencing (scRNA-seq) offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms.
Kyung Dae Ko, Vittorio Sartorelli
doaj   +1 more source

6mer seed toxicity in tumor suppressive microRNAs

Nature Communications, 2018
Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences.
Quan Q. Gao, William E. Putzbach, Andrea E. Murmann, Siquan Chen, Aishe A. Sarshad, Johannes M. Peter, Elizabeth T. Bartom, Markus Hafner, Marcus E. Peter   +8 more
doaj   +1 more source

Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation [PDF]

, 2013
Biodegradable scaffolds are widely used to transplant stem cells into various tissues. Recent studies showed that living stem cells can be attached to the surface of absorbable sutures in vitro.
Horváthy, Dénes, Lacza, Zsombor, Renner, Károly, Szabó, Tamás, Sándor, Balázs, Vajda, Kinga, Vácz, Gabriella   +6 more
core   +2 more sources

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Nature Communications, 2017
Cachexia is a metabolic syndrome leading to muscle and adipose tissue loss in majority of cancer patients. Here the authors show that, in a mouse model, BET inhibitor JQ1 counteracts muscle and adipose tissue wasting tempering cachexia and prolonging ...
Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti   +16 more
doaj   +1 more source