Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]
, 2014 Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M +6 more
core +6 more sources
Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]
, 2015 In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia +2 more
core +8 more sources
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources
Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]
, 2012 It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S +7 more
core +1 more source
The role and therapeutic potential of stem cells in skeletal muscle in sarcopenia
Stem Cell Research & Therapy, 2022 Sarcopenia is a common age-related skeletal muscle disorder featuring the loss of muscle mass and function. In regard to tissue repair in the human body, scientists always consider the use of stem cells.
Zijun Cai +9 more
doaj +1 more source
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation
Nature Communications, 2023 Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells.
Marlies Cortés +17 more
doaj +1 more source
Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. [PDF]
, 2017 Implanted biomaterials and biomedical devices generally induce foreign body reaction and end up with encapsulation by a dense avascular fibrous layer enriched in extracellular matrix.
Chu, Julia +9 more
core +2 more sources
HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]
, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
core +3 more sources
Non Muscle Stem Cells and Muscle Regeneration [PDF]
, 2008 Skeletal muscle of the vertebrate embryo originates from paraxial mesoderm (somites, somitomers and prechordal cephalic mesoderm) (Christ and Ordahl 1995) and is formed in discrete steps by different classes of myogenic progenitor cells (Cossu and Biressi 2005).
G. Messina, S. Biressi, G. Cossu
openaire +2 more sources
Mechanosensitivity of aged muscle stem cells [PDF]
Journal of Orthopaedic Research, 2017 ABSTRACTDuring aging, skeletal muscle tissue progressively declines in mass, strength, and regenerative capacity. Decreased muscle stem cell (MuSC) number and impaired function might underlie the aging‐related muscle wasting and impaired regenerative capacity.
Boers, Heleen +5 more
openaire +6 more sources