Results 21 to 30 of about 3,653 (216)

­­­Mechanosensitivity of aged muscle stem cells [PDF]

Journal of Orthopaedic Research, 2017
ABSTRACTDuring aging, skeletal muscle tissue progressively declines in mass, strength, and regenerative capacity. Decreased muscle stem cell (MuSC) number and impaired function might underlie the aging‐related muscle wasting and impaired regenerative capacity.
Boers, Heleen, Haroon, Mohammad, Le Grand, Fabien, Bakker, Astrid, Klein-Nulend, Jenneke, Jaspers, Richard   +5 more
openaire   +6 more sources

Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells

Cell Reports, 2016
Summary: The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However,
Aster H. Juan, Stan Wang, Kyung Dae Ko, Hossein Zare, Pei-Fang Tsai, Xuesong Feng, Karinna O. Vivanco, Anthony M. Ascoli, Gustavo Gutierrez-Cruz, Jordan Krebs, Simone Sidoli, Adam L. Knight, Roger A. Pedersen, Benjamin A. Garcia, Rafael Casellas, Jizhong Zou, Vittorio Sartorelli   +16 more
doaj   +1 more source

The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation

Cell Reports, 2017
The CCHC-type zinc finger nucleic acid-binding protein (CNBP/ZNF9) is conserved in eukaryotes and is essential for embryonic development in mammals. It has been implicated in transcriptional, as well as post-transcriptional, gene regulation; however, its
Daniel Benhalevy, Sanjay K. Gupta, Charles H. Danan, Suman Ghosal, Hong-Wei Sun, Hinke G. Kazemier, Katrin Paeschke, Markus Hafner, Stefan A. Juranek   +8 more
doaj   +1 more source

Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

eLife, 2021
Acute skeletal muscle injury is followed by an inflammatory response, removal of damaged tissue, and the generation of new muscle fibers by resident muscle stem cells, a process well characterized in murine injury models. Inflammatory cells are needed to
Ines Lahmann, Joscha Griger, Jie-Shin Chen, Yao Zhang, Markus Schuelke, Carmen Birchmeier   +5 more
doaj   +1 more source

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Nature Communications, 2019
Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated ...
Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke   +9 more
doaj   +1 more source

Function and regulation of muscle stem cells in skeletal muscle development and regeneration: a narrative review

Journal of Bio-X Research, 2021
. Skeletal muscle plays an essential role in generating the mechanical force necessary to support the movement of our body and daily exercise. Compared with cardiac and smooth muscle, in mammals, skeletal muscle exhibits remarkable regenerative capacity ...
Han Zhu, Xin Lin, Yarui Diao
doaj   +1 more source

Modulation of mTOR signaling as a strategy for the treatment of Pompe disease

EMBO Molecular Medicine, 2017
Mechanistic target of rapamycin (mTOR) coordinates biosynthetic and catabolic processes in response to multiple extracellular and intracellular signals including growth factors and nutrients. This serine/threonine kinase has long been known as a critical
Jeong‐A Lim, Lishu Li, Orian S Shirihai, Kyle M Trudeau, Rosa Puertollano, Nina Raben   +5 more
doaj   +1 more source

Aging, metabolism and stem cells: Spotlight on muscle stem cells [PDF]

Molecular and Cellular Endocrinology, 2017
All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype.
García-Prat, Laura, Munoz-Canoves, Pura
openaire   +3 more sources

A deep learning framework for denoising and ordering scRNA-seq data using adversarial autoencoder with dynamic batching

STAR Protocols
Summary: Single-cell RNA sequencing (scRNA-seq) provides high resolution of cell-to-cell variation in gene expression and offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms. However, technical challenges such as low
Kyung Dae Ko, Vittorio Sartorelli
doaj   +1 more source

A deep learning adversarial autoencoder with dynamic batching displays high performance in denoising and ordering scRNA-seq data

iScience
Summary: By providing high-resolution of cell-to-cell variation in gene expression, single-cell RNA sequencing (scRNA-seq) offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms.
Kyung Dae Ko, Vittorio Sartorelli
doaj   +1 more source