Results 151 to 160 of about 5,165,603 (261)

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

The Prevalence of Work-Related Musculoskeletal Disease Among Pediatric Ophthalmologists. [PDF]

Clin Ophthalmol, 2022
Fouzdar Jain S, Akhter S, Ishihara R, Siddicky S, High R, Suh DW.   +5 more
europepmc   +1 more source

Pathological Assessment of Metastatic Disease to the Musculoskeletal System

The musculoskeletal system is a common site for metastases in advanced cancer. Metastases are associated with poor prognosis, and their detection is crucial for proper treatment.
Rosenberg, Andrew E., Diaz-Perez, Julio A.   +1 more
core   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery. [PDF]

Trends Biotechnol
Gao Q, Lee ML, Makarczyk M, Chow SK, Bunnell BA, Lin H, Goodman SB.   +6 more
europepmc   +1 more source

Safety of third-dose SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal disease. [PDF]

Rheumatology (Oxford), 2022
Connolly CM, Frey S, Chiang TP, Teles M, Alejo JL, Albayda J, Shah AA, Werbel WA, Segev DL, Christopher-Stine L, Paik JJ.   +10 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Muscle in fat trouble: The rise of IMAT in metabolic and musculoskeletal disease. [PDF]

Mol Metab
Weik VM, Birkenfeld AL, Peter A, Weigert C, Dreher SI.   +4 more
europepmc   +1 more source

Current use of biologic therapies for musculoskeletal disease: A survey of board-certified equine specialists. [PDF]

Vet Surg, 2022
Knott LE, Fonseca-Martinez BA, O'Connor AM, Goodrich LR, McIlwraith CW, Colbath AC.   +5 more
europepmc   +1 more source

Fourth Meeting European Musculoskeletal Oncology Society

, 1991
Fourth Meeting European Musculoskeletal Oncology ...
M. CAMPANACCI, CAPANNA, RODOLFO, A. T. AYDIN, D. CAMPANACCI, M. MANFRINI, D. DONATI, G. L. CAPELLO, P. PICCI   +7 more
core