Results 71 to 80 of about 3,783,177 (235)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A relação entre teoria e prática na formação tecnológica do educador

Cadernos Cajuína
A pesquisa tratou da relação entre teoria e prática na formação tecnológica do educador, buscando compreender de que modo essa articulação tem ocorrido nos processos formativos docentes.
Denise Amorim Guedes Faria, Elenice Abadia Dourado, Emilituani Narzzetti da Cruz, Iasmim Hévila Ferreira dos Santos, Lucas Guimarães Matos de Santana, Marta Lúcia Ferreira da Silva, Rannielly Wend Cunha Silva, Sarha Morais Pereira, Suelena de Souza Silva   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Tecnologias educacionais e a reconfiguração dos currículos escolares

Cadernos Cajuína
O estudo abordou a relação entre as tecnologias educacionais e a reconfiguração dos currículos escolares, analisando como essas transformações influenciaram as metodologias de ensino.
Silvana Maria Aparecida Viana Santos, Alessandra Jorge Abbadia de Queiroz, Claudio Henrique Lopes de Barros, Danielli Cristina Machado Lidugério, Cristiane Jorge Abbadia de Queiroz, Cleberson Cordeiro de Moura, Rafael dos Santos Cometti, Tarsio Monteiro Lago   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Currículo, metodologia e tecnologia: a tríade transformadora da educação contemporânea

Cadernos Cajuína
O presente estudo aborda a inter-relação entre currículo, metodologia e tecnologia, compreendendo essa tríade como um elemento fundamental para a renovação das práticas educacionais no século XXI.
Cleberson Cordeiro de Moura, Alessandra Rigonato Vieira, Arlene Antônia da Canceição Assis, Elaine de Jesus Costa Salgado , Eliana Garcia da Silva, Gabriela Clotilde dos Santos Monteiro, Gabriel Gonçalves de Freitas, Thamires Oliveira Cochi   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Gamificação e acessibilidade: caminhos para tornar a aprendizagem mais democrática

Cadernos Cajuína
O estudo partiu do problema de compreender de que maneira a gamificação poderia contribuir para a promoção da acessibilidade e, assim, favorecer a construção de práticas pedagógicas que tornassem a aprendizagem mais democrática.
Maria Cleonice Santos de Melo Penha, Flávia Maria Matos Santos dos Santos, Francisco Fabrício Félix Gonçalves, Janaína Ferreira Gustavo Uchôa, Keila Saboia Diniz, Liliane Rodrigues da Silva Duran, Murilo Alfonso Peixoto, Paulo Roberto Serafini   +7 more
doaj   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source