Results 71 to 80 of about 5,687,054 (304)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

All The Monuments Must Fall: A Syllabus

, 2017
A crowd-sourced syllabus concerning statues, monuments and memorials in the wake of the events in Charlottesville VA in August 2017All The Monuments Must Fall ...
Mirzoeff and many others
core  

Formação docente e gestão da qualidade com perspectivas e lacunas

Cadernos Cajuína
A pesquisa discute as relações entre formação docente e gestão da qualidade na escola pública, com ênfase nas potencialidades, desafios e lacunas que atravessam esse campo no cenário contemporâneo da educação básica.
Ana Paula da Graça, Dárcia Cristina Ribeiro, Dimas Sebastião Borges da Cruz, Elisangela Toretta Zen, Ivete Medeiros Lessa, Natalina Aparecida Pupin, Valquíria da Conceição Costa, Vanessa Braga Libano, Viviane Zanon Bindaco de Oliveira   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

UMPSA Advanced laksana sistem pengambilan MUST [PDF]

KUANTAN: Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) melalui anak syarikatnya. UMPSA Advanced menawarkan laluan khas kepada lepasan Sijil Pelajaran Malaysia (SPM) untuk melanjutkan pengajian di universiti itu secara terus melalui sistem ...
Siti Nur Azwin, Zulkapri
core  

Determination of fungicide pyrimethanil in grapes, must, fermenting must and wine

, 2013
BACKGROUND: This study determined the evolution of pyrimethanil, a fungicide commonly used to control Botrytis cinerea, throughout the winemaking process in grapes, must, fermenting must and wine.
Sanz-Asensio, J., Martínez-Soria, M.-T. [0000-0003-4208-2801], Fernández-Zurbano, P. [0000-0002-4516-9534], López-Alonso, M., Vaquero-Fernández, L.   +4 more
core   +1 more source

Tecnologia e pedagogia: repensando a prática docente à luz de Vygotsky e Freire

Cadernos Cajuína
A pesquisa teve como problema compreender de que forma a integração entre tecnologia e pedagogia, fundamentada nas concepções de Vygotsky e Freire, poderia contribuir para repensar a prática docente e promover aprendizagens significativas e libertadoras.
Silvana Maria Aparecida Viana Santos, Alessandra Côco Marinato, Cláudia de Oliveira Octávio Borges, Denize Vergino, Fernanda Martins Gonçalves Roza, Lúbia Bragança de Oliveira Nascimento, Priscila Freitas da Silva Dalmonech, Sonia Regina da Conceição Carola   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

O papel do professor frente às tecnologias digitais: desafios e possibilidades

Cadernos Cajuína
O presente estudo teve como foco as dificuldades enfrentadas pelos professores no processo de integração das tecnologias digitais ao currículo escolar.
Davi Rodrigues Mendes de Souza, Cristiano Sial da Silva Alves, Alessandra Jorge Abbadia de Queiroz, Cristiane Jorge Abbadia de Queiroz, Claudio Henrique Lopes de Barros, Eliana Garcia da Silva, Fábia de Assis Arão, Ygor Rafael Leite Pereira   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source