Results 91 to 100 of about 5,687,054 (304)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

HBR's 10 Must Reads on Managing People

, 2010
v, 224 hlm.; Ind.; 22 ...
HBR's 10 Must Reads
core  

A relação entre teoria e prática na formação tecnológica do educador

Cadernos Cajuína
A pesquisa tratou da relação entre teoria e prática na formação tecnológica do educador, buscando compreender de que modo essa articulação tem ocorrido nos processos formativos docentes.
Denise Amorim Guedes Faria, Elenice Abadia Dourado, Emilituani Narzzetti da Cruz, Iasmim Hévila Ferreira dos Santos, Lucas Guimarães Matos de Santana, Marta Lúcia Ferreira da Silva, Rannielly Wend Cunha Silva, Sarha Morais Pereira, Suelena de Souza Silva   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

HBR'S 10 Must Reads on Strategic Marketing

, 2013
v, 206 hlm.; Ind.; 22 ...
HBR's 10 Must Reads
core  

Tecnologias educacionais e a reconfiguração dos currículos escolares

Cadernos Cajuína
O estudo abordou a relação entre as tecnologias educacionais e a reconfiguração dos currículos escolares, analisando como essas transformações influenciaram as metodologias de ensino.
Silvana Maria Aparecida Viana Santos, Alessandra Jorge Abbadia de Queiroz, Claudio Henrique Lopes de Barros, Danielli Cristina Machado Lidugério, Cristiane Jorge Abbadia de Queiroz, Cleberson Cordeiro de Moura, Rafael dos Santos Cometti, Tarsio Monteiro Lago   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

HBR's 10 Must Reads on Strategy

, 2010
v, 266 hlm.; Ind.; 22 ...
HBR's 10 Must Reads
core  

Currículo, metodologia e tecnologia: a tríade transformadora da educação contemporânea

Cadernos Cajuína
O presente estudo aborda a inter-relação entre currículo, metodologia e tecnologia, compreendendo essa tríade como um elemento fundamental para a renovação das práticas educacionais no século XXI.
Cleberson Cordeiro de Moura, Alessandra Rigonato Vieira, Arlene Antônia da Canceição Assis, Elaine de Jesus Costa Salgado , Eliana Garcia da Silva, Gabriela Clotilde dos Santos Monteiro, Gabriel Gonçalves de Freitas, Thamires Oliveira Cochi   +7 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source