Results 81 to 90 of about 5,687,054 (304)

Práticas pedagógicas inclusivas mediadas por tecnologias digitais no ensino regular

Cadernos Cajuína
Esta pesquisa analisa práticas pedagógicas inclusivas mediadas por tecnologias digitais no ensino regular, a partir de uma Pesquisa Bibliográfica fundamentada exclusivamente em produções acadêmicas publicadas a partir de 2020.
Cleberson Cordeiro de Moura, Almir Sampaio de Moura, Alexandre Fabiani Accorsi do Amaral, Graciana De Assis Cunha Manoel, Josianne Cavalcanti Gomes Machado, Ismael Dos Santos Oliveira, Késia Nascimento da Cruz Rodolfo, Letícia de Andrade Ferreira Oliveira, Rannielly Wend Cunha Silva Oliveira   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Academics must keep abreast of teaching methods

, 2023
The upcoming review of the National Higher Education Policy by the Higher Education Ministry is timely to steer the national conversation towards improving teaching.
William K., Lim
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

HBR's 10 Must Reads on Leadership

, 2010
v, 217 hlm.; Ind.; 22 ...
HBR's 10 Must Reads
core  

Antike in Schule und Museum. Zur Orientierung in Curricula, Didaktik und Museumspädagogik

, 2022
Must T. Antike in Schule und Museum. Zur Orientierung in Curricula, Didaktik und Museumspädagogik. In: Must T, ed. Relevanz der Antike im Sachunterricht. Eine Frage von Lebensweltbezug, Standort und Themenwahl. Gespräche zum Sachunterricht.
Must, Thomas ; https://orcid.org/, Must, Thomas   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The War in Ukraine Must Stop Now [PDF]

, 2022
The extreme dangers of nuclear war are discussed against the background of Russia’s brutal and illegal invasion of Ukraine, during which Vladimir Putin put Russia’s nuclear weapons on high alert.
John Scales Avery
core  

Ferramentas tecnológicas como mediadoras da inclusão escolar de estudantes neurodiversos

Cadernos Cajuína
O estudo teve como propósito compreender de que maneira as ferramentas tecnológicas atuaram como mediadoras da inclusão escolar de estudantes neurodiversos, analisando seus efeitos sobre o processo de aprendizagem e o desenvolvimento cognitivo e social.
Ray Luiz Babilon Carreço, Andressa Santana Inácio de Rezende, Ariele Branício de Souza Lemes, Cleberson Cordeiro de Moura, Denise Regina da Silva, Denise de Paula Silva Almeida, Elizete Moreira dos Santos, Lilia Adriana Lançanova, Marcilene Pereira Souza   +8 more
doaj   +1 more source