Results 41 to 50 of about 28,635 (297)
Frontiers in Microbiology, 2023 Microalgae are a large group of organisms that can produce various useful substances through photosynthesis. Microalgae need to be genetically modified at the molecular level to become “Chassis Cells” for food, medicine, energy, and environmental ...
Xiaobing Hu +6 more
doaj +1 more source
PiggyBac Transposon-Based Insertional Mutagenesis in Mice
, 2019 While sequencing and array-based studies are creating catalogues of genetic alterations in cancer, discriminating cancer drivers among the large sets of epigenetically, transcriptionally or posttranslationally dysregulated genes remains a challenge ...
Bronner, IF +4 more
core +1 more source
, 2022 Supplementary Figure from In Vitro Insertional Mutagenesis Screen Identifies Novel Genes Driving Breast Cancer ...
Csaba Miskey (466684) +8 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
PLoS Computational Biology, 2018 Haploid cells are increasingly used for screening of complex pathways in animal genomes. Hemizygous mutations introduced through viral insertional mutagenesis can be directly selected for phenotypic changes.
Giulio Di Minin +2 more
doaj +1 more source
Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation
Cell Reports, 2016 To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses.
Jianqiang Wu +22 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution
Cell Reports, 2018 Summary: LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear.
Thu H.M. Nguyen +22 more
doaj +1 more source
Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens. [PDF]
PLoS Computational Biology, 2006 Retroviral insertional mutagenesis screens, which identify genes involved in tumor development in mice, have yielded a substantial number of retroviral integration sites, and this number is expected to grow substantially due to the introduction of high ...
Jeroen de Ridder +4 more
doaj +1 more source
Retroviral-mediated Insertional Mutagenesis in Zebrafish [PDF]
, 2011 Since the initial publication of this chapter in 2004, additional methodologies have been developed which could improve and/or complement the original retroviral-mediated insertional mutagenesis. Retroviral vectors have also been shown to be useful for goals other than mutagenesis.
Adam, Amsterdam +2 more
openaire +2 more sources