Results 181 to 190 of about 3,838,500 (295)

Genetic Alterations Shaping the Functional Properties of DyP Peroxidases. [PDF]

ACS Omega
Saad MM, Habib MH, ElRakaiby MT, Mourad FE.   +3 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Tuning the F695 fluorescent state in photosystem II using site-directed mutagenesis in Synechocystis sp. PCC 6803. [PDF]

Photosynth Res
Phadkule A, Srivastava A, Martin AA, Dome LG, McKenzie SD, Puthiyaveetil S, Reppert M.   +6 more
europepmc   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Discovery and evolution of an (<i>R</i>)-selective transaminase for production of sitagliptin. [PDF]

RSC Chem Biol
Treadell M, Surman GRE, Ford GJ, Otun CW, Srinivasan SJ, Galman J, Bawn M, Pandya A, Markin CJ, Green AP, Rowbotham JS.   +10 more
europepmc   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Functional importance of Asp264 in the ketosynthase domain of Pks13 in <i>Mycobacterium smegmatis</i>. [PDF]

Cell Surf
Modak M, Ghadbane H, Futterer K, Bhatt A, Besra GS.   +4 more
europepmc   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Method of Site-Directed Mutagenesis Using Long Primer-Unique Site Elimination and Exonuclease III

BioTechniques, 1997
G. Nicolas, S. Pedroni, C. Fournier, H. Gautero, M.-C. Lecomte   +4 more
doaj   +1 more source

Engineering dextranase for the directed preparation of low-molecular-weight dextran. [PDF]

Food Chem (Oxf)
Qin Y, Ren Y, Tong L, Liang G, Yuan Y, Meng L, Zhang H, Wang Q.   +7 more
europepmc   +1 more source