Results 101 to 110 of about 470,712 (310)
Radiation Oncology, 2018 Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy.
Guido Fròsina +5 more
doaj +1 more source
Primers of site-directed mutagenesis.
, 2014 Primers of site-directed mutagenesis.
Cheng Liu (83733) +3 more
core +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Oligonucleotides used for general cloning and site-directed mutagenesis.
, 2015 Nucleotides altered by site directed mutagenesis are underlined.Oligonucleotides used for general cloning and site-directed mutagenesis.
Beate Sodeik (191751) +7 more
core +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Mutagenesis by overlapping PCR reaction.
, 2013 Mutagenesis by overlapping PCR reaction.
Daniel Mayer (369790) +6 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
, 2012 The first attempts to induce mutations in biological systems using chemical compounds go back to the beginning of the past century. However, it was during World War II that the two most relevant names in chemical mutagenesis, Charlotte Auerbach and Iosif A. Rapoport, established the mutagenic properties of several chemical compounds (Box 12.1).
openaire +2 more sources
Primers used for random and site-directed mutagenesis.
, 2013 a, random mutagenesis; b, site-directed mutagenesis. Underline letters indicate the sequence for ligation-independent cloning; Italic letters indicate the mutation nucleotides.
Hanbin Liu (370302) +11 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source