Results 91 to 100 of about 470,712 (310)

Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research [PDF]

, 2016
Mitochondrial diseases have been extensively investigated over the last three decades but many questions regarding their underlying aetiologies remain unanswered.
Paraskevaidi, Maria, Kyrgiou, Maria, Martin, Francis L, Paraskevaidi, M, Martin-Hirsch, PL, Martin, FL, Martin-Hirsch, Pierre L., Kyrgiou, M   +7 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Emerging evidence on micro- and nanoplastics carcinogenicity: mechanisms, models, and signaling networks

Molecular Cancer
Evidence of micro- and nanoplastics (MNPLs) presence in human tissues, cells, and biological fluids raises concerns about their potential role in hazardous diseases, including cancer.
Mohamed Alaraby, Doaa Abass, Ricard Marcos, Alba Hernández   +3 more
doaj   +1 more source

mutagenesis data

, 2018
All the measurements were based on the F2 (male) and F3 (female) offspring after the mutagenesis ...
Pool, John E, Yuheng Huang (610897), Huang, Yuheng, John E Pool (5489657), Groth, Benjamin R, Benjamin R Groth (5489660), Matthew J Monette (5489663), Monette, Matthew J   +7 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

In vitro scanning saturation mutagenesis of proteins [PDF]

, 1998
The present invention combines PCR.TM. mutagenesis with in vitro transcription/translation and ELISA for the rapid generation and characterization of protein mutants. The PCR.TM.
Iverson, Brent L., Burks, Elizabeth A., Georgiou, George M.   +2 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Antimutagenic effects of 2,6-Dimethylpyridine-N-oxide using fluctuation ames test

Toxicology Reports
The mutagenic potential of chemical agents is a significant concern in the field of genetic toxicology. The 2,6-Dimethylpyridine-N-oxide is believed to have antimutagenic properties, which could be beneficial for applications in pharmaceutical and ...
Olesia Vasetska, Volodymyr Bubalo, Tetyana Usenko, Petro Zhminko, Mykola Prodanchuk   +4 more
doaj   +1 more source

RNAseq analysis reveals pathways and candidate genes associated with salinity tolerance in a spaceflight-induced wheat mutant

Scientific Reports, 2017
Salinity stress has become an increasing threat to food security worldwide and elucidation of the mechanism for salinity tolerance is of great significance.
Hongchun Xiong, Huijun Guo, Yongdun Xie, Linshu Zhao, Jiayu Gu, Shirong Zhao, Junhui Li, Luxiang Liu   +7 more
doaj   +1 more source