Results 231 to 240 of about 470,712 (310)

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

A new conceptual framework for PKD1 in ADPKD; integrating DNA structures and inflammation. [PDF]

BMC Nephrol
Hanakahi LA, Subrahmanyan T, Vanden Heuvel GB, Larson ED.   +3 more
europepmc   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Sequence-free landscape inference for directed evolution. [PDF]

PLoS Comput Biol
Towers S, James J, Steel H, Kempf I.
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing. [PDF]

Nat Commun
Hong M, Luan C, Yuan M, Huang H, Guo X, Meng D, Huang M, Xu Y, Zhao S, Chen K, Chen J, Li D, Chen L.   +12 more
europepmc   +1 more source

Exploiting DNA damage tolerance for precision oncology. [PDF]

Trends Cancer
Bhat A, Lahane GP, Pandita RK, Bacolla A, Hoden B, Ramos KS, Krishnan S, Sarkar PS, Dhar A, Tainer JA, Pandita TK.   +10 more
europepmc   +1 more source

High-throughput mutational analysis of F₁-ATPase by integrated cell-free protein synthesis and single-molecule rotation assay. [PDF]

Protein Sci
Taguchi M, Oya T, Ueno H, Noji H.
europepmc   +1 more source

Engineering of a Carbonic Anhydrase from <i>Hydrogenimonas thermophila</i> Through Fusion Tags and Surface Mutagenesis Enhances Solubility While Revealing Stability-Function Relationships. [PDF]

Int J Mol Sci
Manyumwa CV, Jers C, Mijakovic I.
europepmc   +1 more source