Results 91 to 100 of about 13,277,354 (332)
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons+17 more
wiley +1 more source
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk+4 more
wiley +1 more source
Although the use of medicinal plants or natural products has increased in recent decades all over the world, little information is available on their potential risk to health.
JB. Vilar, PH. Ferri, L. Chen-Chen
doaj +1 more source
Toxicology evaluation of selenium protein powder
The experiment was conducted to evaluate the safety of selenium protein powder, a novel organic selenium nutritional supplement, and reported corresponding data and results based on a series of toxicological tests.
Qin Shunyi+4 more
doaj +1 more source
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten+15 more
wiley +1 more source
Presentation of benzo(a)pyrene to microsomal enzymes by asbestos fibers in the Salmonella/mammalian microsome mutagenicity test. [PDF]
K. Szyba, Andrzej Lange
openalex +1 more source
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl+14 more
wiley +1 more source
Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li+7 more
wiley +1 more source
Epidemiology, multistage models, and short-term mutagenicity tests.
R. Peto
semanticscholar +1 more source
Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang+23 more
wiley +1 more source