Results 81 to 90 of about 10,901 (213)

Mutagenicity of acrylonitrile. [PDF]

open access: yes, 1978
Incubation of Salmonella typhimurium strains in an atmosphere of 0.2% gaseous acrylonitrile increased the numbers of his+ revertants/plate only in the presence of a fortified S9 liver fraction.
De Meester, Conrad   +3 more
core  

The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity. [PDF]

open access: yes, 2013
Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31 their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32 evant toxicological endpoints to avoid
Rorije, E.   +9 more
core  

Can a simple test in bacteria identify cancer-causing chemicals in humans?

open access: yesBJHS Themes
Since the 1950s, US officials have sought to reduce cancer incidence by regulating chemical exposures. However, rodent carcinogenicity tests are lengthy and expensive, making it impractical to identify carcinogens among the tens of thousands of chemicals
Angela N. H. Creager
doaj   +1 more source

Mutagenicity and Anticholinesterase Activity of Some Possible Metabolites of Aryl N-Methylcarbamates [PDF]

open access: yes
Some possible metabolites of carbaryl including demethyl, hydroxymethyl, N-hydroxy, and N-nitroso derivatives and of phenyl N-methylcarbamate were examined for mutagenicity using the mutants of Salmonella typhimurium (Ames test) and B a - cillus subtilis
Eto, morifusa   +11 more
core  

Reduction in genotoxic effects of explosives-contaminated soil by composting as determined by the Salmonella typhimurium microsomal mutagenicity assay [PDF]

open access: yes, 1994
Composting of soils contaminated with the explosives 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro- 1,3,5,7-tetraazocine (HMX) was evaluated in a field study for its ability to detoxify and ...
Ironside, Kevin S.
core   +1 more source

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme [PDF]

open access: yes, 2017
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity.
Cimino, Michael C.   +9 more
core  

Evaluation of the genotoxic potential of ethanolic extracts of stem bark and leaves of Bathysa cuspidata (A.St.-Hil.) Hook

open access: yesRevista de Ciências Farmacêuticas Básica e Aplicada, 2012
Bathysa cuspidata (A.St.-Hil.) Hook. is a native tree of the Brazilian Atlantic Forest biome, widely used in Brazilian herbal medicine. Despite its widespread use, there is no report as yet regarding the toxicology of this plant.
Douglas Costa Gontijo   +4 more
doaj   +2 more sources

Genotoxicity investigation of araticum(Annona crassiflora Mart., 1841, Annonaceae) using SOS-Inductest and Ames test

open access: yesBrazilian Journal of Biology
Although the use of medicinal plants or natural products has increased in recent decades all over the world, little information is available on their potential risk to health.
JB. Vilar, PH. Ferri, L. Chen-Chen
doaj   +1 more source

In vitro cytotoxicity and genotoxicity assessment of methanolic extracts of vanillas from Brazilian biodiversity with commercial potential

open access: yesToxicology Reports
The Vanilla genus is crucial for global production in food, perfume, and pharmaceutical industries. However, exploitation threatens some species, leading to extinction.
Natália Gonçalves Ribeiro Araujo   +4 more
doaj   +1 more source

樟树籽仁油的遗传毒性评价

open access: yesZhongguo youzhi
为评价樟树籽仁油的食用安全性,通过细菌回复突变试验、体外哺乳类细胞TK基因突变试验及哺乳动物红细胞微核试验探究樟树籽仁油的致突变和潜在致癌作用。结果表明:樟树籽仁油对组氨酸缺陷型鼠伤寒沙门氏菌TA1535、TA97、TA98、TA100、TA102均无致突变作用;樟树籽仁油未抑制L5178Y小鼠淋巴瘤细胞的生长,对体外哺乳类细胞TK基因无致突变作用;樟树籽仁油未导致小鼠细胞微核率上升,对哺乳动物红细胞无致突变作用,无遗传毒性。综上,樟树籽仁油无细胞致突变和潜在致癌作用,没有遗传毒性,具有一定的食用安全性。
彭婷1,2,3,梁丽军4,曾哲灵1,2,5,张淑虹1,5,鄢祥辉1,2,6,夏佳恒1,2,5,余平1,2,5, 万冬满1,2,3,文学方7,8 PENG Ting1,2,3, LIANG Lijun4, ZENG Zheling1,2,5, ZHANG Shuhong1,5, YAN Xianghui1,2,6, XIA Jiaheng1,2,5, YU Ping1,2,5, WAN Dongman1,2,3, WEN Xuefang7,8
doaj   +1 more source

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