Results 61 to 70 of about 15,527,587 (352)
Biomedical Papers, 2015 Aim: The purpose of this study was to prepare a coladerm-beta glucan membrane (CBGM) and to evaluate its biocompatibility, cytotoxicity, antimicrobial activity, genotoxicity and mutagenicity.
Sona Jantova +3 more
doaj +1 more source
Futility Analysis in the Cross-Validation of Machine Learning Models [PDF]
, 2014 Many machine learning models have important structural tuning parameters that cannot be directly estimated from the data. The common tactic for setting these parameters is to use resampling methods, such as cross--validation or the bootstrap, to evaluate
Kuhn, Max
core
MUTAGENICITY TEST OF HALOPREDONE ACETATE
The Journal of Toxicological Sciences, 1985 The mutagenicity of halopredone acetate (THS-201) was investigated by means of reverse mutation test in seven bacterial strains (S. typhimurium TA100, TA1535, TA98, TA1538, TA1537 and E. coli WP2, WP2 uvrA) and chromosomal aberration test in cultured Chinese hamster cells (CHL).
A, Ohuchida, R, Yoshida, K, Morita
openaire +3 more sources
Angewandte Chemie International Edition, EarlyView.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Protective Effects of Lycopene and Coenzyme Q10 Against 5-Fluorouracil-Induced Genotoxicity in SW480 (Colorectal Cancer) and Bone Marrow Mesenchymal Stem Cells Cell Lines: A Comet Assay Study [PDF]
مجله دانشگاه علوم پزشکی گرگانBackground and Objective: 5-fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer treatment; however, its genotoxicity can lead to deoxyribonucleic acid (DNA) damage in healthy cells.
Elahe Gharehkhani +4 more
doaj
Genotoxicity of Di (2-ethyl hexyl) phthalate
Zhongguo shipin weisheng zazhi, 2022 ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome ...
LI Juntao +9 more
doaj +1 more source
EURL ECVAM strategy to avoid and reduce animal use in genotoxicity testing [PDF]
, 2013 The assessment of genotoxicity represents an important component of the safety assessment of all types of substances. Although several in vitro tests are available at different stages of development and acceptance, they cannot at present be considered to
CORVI Raffaella +3 more
core +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
An Ensemble Model of QSAR Tools for Regulatory Risk Assessment [PDF]
, 2016 Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect.
Merrill, Stephen +3 more
core +4 more sources