Results 51 to 60 of about 10,959 (312)
Mutagenicity testing for chemical risk assessment: Update of the WHO/IPCS harmonized scheme
, 2022 S.341-349Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity.
Cimino, M.C. +9 more
core +2 more sources
In silico Prediction of Chemical Ames Mutagenicity
, 2016 Mutagenicity is one of the most important end points of toxicity. Due to high cost and laboriousness in experimental tests, it is necessary to develop robust in silico methods to predict chemical mutagenicity.
Congying Xu (2019421) +7 more
core +2 more sources
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Protective Effects of Lycopene and Coenzyme Q10 Against 5-Fluorouracil-Induced Genotoxicity in SW480 (Colorectal Cancer) and Bone Marrow Mesenchymal Stem Cells Cell Lines: A Comet Assay Study [PDF]
مجله دانشگاه علوم پزشکی گرگانBackground and Objective: 5-fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer treatment; however, its genotoxicity can lead to deoxyribonucleic acid (DNA) damage in healthy cells.
Elahe Gharehkhani +4 more
doaj
Biomedical Papers, 2015 Aim: The purpose of this study was to prepare a coladerm-beta glucan membrane (CBGM) and to evaluate its biocompatibility, cytotoxicity, antimicrobial activity, genotoxicity and mutagenicity.
Sona Jantova +3 more
doaj +1 more source
Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells
Advanced Intelligent Systems, EarlyView.Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer +6 more
wiley +1 more source
, 1999 As an index for evaluation of marine environmental pollution by spilled C heavy oil from the sunken vessel Nakhodka, we carried out mutagenic activity tests of several fishes. Some gave positive results in direct and indirect mutagenicity tests.
任, 恵峰 +5 more
core +1 more source
Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease
American Journal of Hematology, EarlyView.ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain +10 more
wiley +1 more source
Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues
Advanced NanoBiomed Research, EarlyView.Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt +4 more
wiley +1 more source