Results 71 to 80 of about 10,959 (312)

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir–ritonavir in patients with COVID‐19

British Journal of Clinical Pharmacology, EarlyView.
Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman, Laura Buggiotti, Li‐An K. Brown, Jose A. Guerra‐Assuncao, Japhette E. Kembou‐Ringert, Wen Y. Mak, Judith Breuer, David M. Lowe, Joseph F. Standing, FLARE Investigators   +9 more
wiley   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Valorization of Yacon (Smallanthus sonchifolius) peel for peroxidase production and its immobilization on alginate beads for 2,4‐dichlorophenol bioconversion

The Canadian Journal of Chemical Engineering, EarlyView.
Sodium alginate was modified with EDC/NHS for the immobilization of Yacon peel peroxidase, resulting in a novel biocatalyst for the oxidation of 2,4‐dichlorophenol. Abstract Yacon (Smallanthus sonchifolius) roots are emerging as an alternative source of peroxidase. This study aimed to extract, immobilize, and characterize the peroxidase from Yacon peel,
Mariana Gomes Oliveira, Marcela Pires Spaolonzi, Carla Ivane Ganz Vogel, Aniela Pinto Kempka, Everton Skoronski   +4 more
wiley   +1 more source

Topological structural alerts modulations of mammalian cell mutagenicity for halogenated derivatives [PDF]

, 2013
Genotoxicity is a key toxicity endpoint for current regulatory requirements regarding new and existing chemicals. However, genotoxicity testing is time-consuming and costly, and involves the use of laboratory animals. This has motivated the development
Combes, R. D., Morales Helguera, Aliuska, Borges, F., Gil Izquierdo, Francisco, Pérez Garrido, Alfonso   +4 more
core   +1 more source

Statistical Learning Model for In-Silico Mutagenicity Prediction

, 2021
Toksisite testleri arasında, bir etken nedeniyle ortaya çıkabilecek genetikdeğişim (mutasyon) olarak tanımlanabilen?mutajenisite önemli yer tutmaktadır.?Buçalışmada genel olarak mutajenisite belirleme sürecini iyileştirebilmek adına insilico?yaklaşım ...
Gümüştaş, Enis, Pehlivanlı, Ayça Çakmak   +1 more
core   +1 more source

Spouted bed drying parameters and adjuvant effects on polyphenol retention and antioxidant activity in mango peel powders

The Canadian Journal of Chemical Engineering, EarlyView.
Spouted bed drying of mango peels with colloidal SiO2 and corn starch produces a free‐flowing powder with reduced agglomeration, increased drying yield, and preserved antioxidant and polyphenol content. Abstract The production of polyphenol‐rich powders is a promising strategy for valorizing agro‐industrial byproducts. This study evaluated drying yield,
Guilherme Henrique Alves Pinto, Fábio Bentes Freire, José Teixeira Freire, Wanderley Pereira Oliveira   +3 more
wiley   +1 more source

Biodegradability, toxicity and mutagenicity of detergents: integrated experimental evaluations.

, 2012
The widespread use of detergents has raised concern with regard to the environmental pollution caused by their active ingredients, which are biorefractory, toxic and persistent.
Gozio E., GELATTI, Umberto, PEDRAZZANI, Roberta, BERTANZA, Giorgio, CERETTI, Elisabetta, Casale R., DONATO, Francesco, ZERBINI, Ilaria, FERETTI, Donatella   +8 more
core   +1 more source

Lack of mutagenicity, genotoxicity and developmental toxicity in safety assessment tests of Lactobacillus mali APS1.

PLoS ONE, 2018
Lactobacillus (L.) mali APS1 isolated from sugary kefir grains has been proven to affect energy and glucose homeostasis. However, without proper safety assessment it cannot be recommended as probiotics for human consumption.
Yu-Chun Lin, Yung-Tsung Chen, Ming-Ju Chen   +2 more
doaj   +1 more source

MUTAGENICITY TESTS OF ETOPOSIDE AND TENIPOSIDE

The Journal of Toxicological Sciences, 1986
Mutagenicities of Etoposide (VP 16-213) and Teniposide (VM-26), podophyllotoxin derivatives with antitumor activity, were studied by Rec-assay, Salmonella/microsome reverse mutation assay (Ames' test) and Micronucleus test. In the Rec-assay, both Etoposide and Teniposide showed positive results on B. subtilis H17 rec+ and M45 rec-.
NAKANOMYO, Hiroshi, HIRAOKA, Masaki, SHIRAYA, Mayumi   +2 more
openaire   +3 more sources

Green and sustainable synthesis of magnetite from copper slag via citrate complexation for methylene blue dye removal from water

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study proposes a novel, green, and sustainable method for synthesizing magnetic iron oxides from metallurgical copper slag (CS), leveraging its iron content as a valuable resource. Iron was extracted via acid leaching using edible citric acid (ECA), forming a citrate–iron complex (CSL), which was subsequently thermally decomposed at 300°C
Melisa Portilla‐Sangabriel, Karen Valencia García, Tania‐Ariadna García‐Mejía, Agileo Hernández‐Gordillo, Rosa‐María Ramírez‐Zamora   +4 more
wiley   +1 more source