British Journal of Clinical Pharmacology, EarlyView.Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang +7 more
wiley +1 more source
Scientific Opinion on Flavouring Group Evaluation 63, Revision 3 (FGE.63Rev3): aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th and 69th meetings) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07Rev4 [PDF]
, 2017 Publisher ...
Binderup, Mona-Lise +29 more
core +3 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman +9 more
wiley +1 more source
Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their revaluation [PDF]
, 2017 The threshold of toxicological concern (TTC) approach is a resource-effective de minimismethod for the safety assessment of chemicals, based on distributional analysis of the results of a large number of toxicological studies.
Abigail Jacobs +22 more
core +2 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Microbial production of 1,3‐butanediol (1,3‐BDO) offers a renewable route to this versatile C4 chemical. However, the low performance of CoA‐acylating butyraldehyde dehydrogenase (Bld), which contains a catalytic cysteine, limits efficient production in recombinant Escherichia coli (E. coli).
Seunghyun Cho +5 more
wiley +1 more source
Introduction and Removal of Disinfection Byproducts and Mutagenic Activity by Chemical and Photolytic Treatments [PDF]
, 1995 La désinfection des eaux de consommation par chloration est connue comme étant à l'origine de la formation de sous-produits organochlorés. Certains de ces sous produits présentent une activité mutagène.
Backlund, P.
core +1 more source
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements
Journal of Toxicology, 2018 Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But ...
Boddapati Srinivasa Rao +8 more
doaj +1 more source
Carbon Energy, EarlyView.The inverted F‐type ZnWO4/In2S3 heterojunction enables efficient charge separation and retention of strong oxidative capability through interfacial electric field regulation, leading to non‐toxic degradation of contaminants for sustainable water treatment.
Yanxian Jin +9 more
wiley +1 more source
Bioscience JournalCampomanesia sessiliflora (O.Berg) Mattos is a Brazilian native plant species used in a popular medicinal tea for treating gastrointestinal, urinary, and dermatological pathologies.
Anahy Arruda Burigato +8 more
doaj +1 more source