Results 151 to 160 of about 13,277,354 (332)

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

open access: yesBritish Journal of Pharmacology, EarlyView.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama   +2 more
wiley   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia   +15 more
wiley   +1 more source

In vitro cytotoxicity and genotoxicity assessment of methanolic extracts of vanillas from Brazilian biodiversity with commercial potential

open access: yesToxicology Reports
The Vanilla genus is crucial for global production in food, perfume, and pharmaceutical industries. However, exploitation threatens some species, leading to extinction.
Natália Gonçalves Ribeiro Araujo   +4 more
doaj  

Red era: Dyeing yak hair fibres red with in situ generated silver nanoparticles using silver nitrate and a flavonoid‐containing plant extract

open access: yesColoration Technology, EarlyView.
Abstract Plants and their extracts have been used for dyeing fabrics, skin and hair for thousands of years and have been experiencing a revival in the last years due to increasing health risks arising from oxidative hair dye precursors. We developed a novel two‐step method to dye keratin fibres based on in situ formed silver nanoparticles including a ...
Julia K. Hachmann   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy