Multiple Instance Learning Improves Ames Mutagenicity Prediction for Problematic Molecular Species [PDF]
, 2023 The prediction of Ames mutagenicity continues to be a concern in both regulatory and pharmacological toxicology. Traditional quantitative structure–activity relationship (QSAR) models of mutagenicity make predictions based on molecular descriptors ...
Raymond Lui (11665019) +3 more
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Antibiotics, 2021 Peroxynitrite (ONOO−) and peroxynitrous acid (ONOOH) are known as short acting reactive species with nitrating and oxidative properties, which are associated with their antimicrobial effect.
Martina Balazinski +3 more
doaj +1 more source
Genotoxic and cytotoxic potential of essential oils from plants of the Cerrado and southern Pantanal of Mato Grosso do Sul, Brazil [PDF]
Brazilian Journal of BiologyCancer represents a major public health concern, and the therapeutic potential of medicinal plants has been extensively studied as an alternative approach for its treatment.
J. A. Avanci-Júnior +7 more
doaj +1 more source
Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]
, 2006 The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Gauthier, Laury +11 more
core +1 more source
AEROSOL MUTAGENICITY IN SAN BERNARDINO, CALIFORNIA VIA BACTERIAL FLUCTUATION TESTS [PDF]
, 2023 San Bernardino, California’s poor air quality is a health risk to its population with some of the highest concentrations of ozone and aerosol in the United States. Aerosols are solid or liquid particles suspended in the air. Smaller aerosol particles are
Murphy, Sean
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Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]
, 2003 The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Gauthier, Laury +4 more
core +1 more source
Cytotoxicity and genotoxicity of calcium silicate-based cements on an osteoblast lineage
Brazilian Oral Research, 2016 Several calcium silicate-based biomaterials have been developed in recent years, in addition to Mineral Trioxide Aggregate (MTA). The aim of this study was to evaluate the cytotoxicity, genotoxicity and apoptosis/necrosis in human osteoblast cells (SAOS ...
Ana Lívia GOMES-CORNÉLIO +7 more
doaj +1 more source
The OSIRIS weight of evidence approach: ITS mutagenicity and ITS carcinogenicity [PDF]
, 2022 S.170-181Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for relevant toxicological endpoints to ...
Pauné, Eduard +10 more
core +1 more source
Evaluation of Some Cytogenetic Effects of Bt.ASF.1 in Lab.mice [PDF]
Engineering and Technology Journal, 2011 This study was amid to detection the genotoxicity ffect of biocide (Bt-ASF-1) producing from Bacillus thuringiensis ( by oral nutrition ) in inhibition of the Cyclophosphoamide drug in mice (Mus musculus) .
doaj +1 more source
Assessment of methyl methacrylate genotoxicity by the micronucleus test
Brazilian Oral Research, 2013 The aim of this study was to evaluate the genotoxic potential of methyl methacrylate (MMA) vapor by simulating standard occupational exposure of 8 hours per day and using the micronucleus test. We used 32 adult male Wistar rats divided into three groups:
Amarildo Mariano de Araújo +4 more
doaj +1 more source