Results 21 to 30 of about 10,901 (213)

Bacterial Mutagenicity Screening in the pharmaceutical industry [PDF]

, 2012
Genetic toxicity testing is used as an early surrogate for carcinogenicity testing. Genetic toxicity testing is also required by regulatory agencies to be conducted prior to initiation of first in human clinical trials and subsequent marketing for most ...
Glowienke, Susanne, Martus, Hans-Joerg, Suter, Willi   +2 more
core   +1 more source

Using Comet Assay for Genotoxic Evaluation of Zataria multiflora Boiss., An Iranian Endemic Plant

Journal of Food Quality and Hazards Control, 2021
Background: Zataria multiflora Boiss. (Avishan-e Shirazi), as an Iranian endemic plant, belongs to the Lamiaceae family and may be used as a food preservative. This study aimed to detect potential genotoxic effects of Z. multiflora extract.
Z. Ayubi, A.A. Jafari, S.A. Ayatollahi-Mousavi, H. Jafari, M. Panddeh   +4 more
doaj  

Characterizing the Chemical Contaminants Diversity and Toxic Potential of Untreated Wastewater From a Drug Rehabilitation Hospital: Understanding Impact on Downstream Environment

Frontiers in Environmental Science, 2022
This study characterizes a total of 21 wastewater samples collected from Al Amal hospital, and aims to determine if untreated hospital wastewater may impose a potentially detrimental impact on the downstream municipal biological wastewater treatment ...
Fras Baasher, Tian-Nyu Wang, Muhammad Zulhelmi Bin Yusnan, Mohsen Alkahtani, Yasir M. Bashawri, Hamed Al Qarni, Pei-Ying Hong, Pei-Ying Hong, Pei-Ying Hong   +8 more
doaj   +1 more source

Metabolic-activation of Drugs in Mutagenicity Tests Invitro [PDF]

, 1980
The metabolic pathways of chemical compounds of pharmaceutical interest are reviewed in relation to the role of activation and detoxification in the process of mutagenicity.
Roberfroid, Marcel, Roberfroid, MB.
core   +1 more source

Mutagenicity evaluation to UV filters of benzophenone-6, benzophenone-8, and 4-methylbenzylidene camphor by Ames test.

PLoS ONE, 2021
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem.
Jing Zhang, Zhou-Tao Pei, Ya-Ni Zhao, Meng Zhang, Li-Ling Zhang, Wen-Qiang Wang, Jing-Ya Wu, Ran Yu, Li-Wei Sun   +8 more
doaj   +1 more source

Degradation of Aflatoxin B₁ in Moldy Maize by Pseudomonas aeruginosa and Safety Evaluation of the Degradation Products

Foods, 2023
Aflatoxin B1 (AFB1) is the most harmful mycotoxin commonly found in food and feed. Pollution from AFB1 causes serious economic and health issues worldwide because it causes strong mutagenicity and carcinogenicity in humans and animals.
Yanhua Xu, Renyong Zhao, Chenxi Liu
doaj   +1 more source

Mutagenicity testing for chemical risk assessment: Update of the WHO/IPCS harmonized scheme [PDF]

, 2022
S.341-349Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity.
Cimino, M.C., Hartwig, A., Dobrev, I., Nohmi, T., Anderson, D., Eastmond, D.A., Douglas, G.R., Vickers, C., Phillips, D.H., Anwar, W.A.   +9 more
core   +3 more sources

In silico Prediction of Chemical Ames Mutagenicity [PDF]

, 2016
Mutagenicity is one of the most important end points of toxicity. Due to high cost and laboriousness in experimental tests, it is necessary to develop robust in silico methods to predict chemical mutagenicity.
Congying Xu (2019421), Zheng Du (2019415), Weihua Li (144468), Feixiong Cheng (151564), Yun Tang (151578), Guixia Liu (151574), Philip W. Lee (2019418), Lei Chen (54296)   +7 more
core   +3 more sources

Genotoxicity evaluation of magnesium salts of isobutyrate and 2-methylbutyrate

Toxicology Reports, 2021
Results of genotoxicity studies for magnesium salts of isobutyrate and 2-methylbutyrate, two candidate ingredients for inclusion in animal feed, are described in this manuscript.
Laurie C. Dolan, Paola Ciliutti, Laura Bisini, Cristina Marabottini, Brian Curtin   +4 more
doaj   +1 more source

Genotoxicity and mutagenicity assessment of a standardized extract (P2Et) obtained from Caesalpinia spinosa

Toxicology Reports, 2021
The standardized P2Et extract obtained from Caesalpinia spinosa has shown antioxidant, and direct antitumor activity, but also activation of specific immune response through the induction of tumor immunogenic cell death in breast and melanoma cancer ...
R. Ballesteros-Ramírez, M.I. Durán, S. Fiorentino   +2 more
doaj   +1 more source