Results 201 to 210 of about 2,851,396 (315)

Development of chalcones structure‐related to avobenzone: Photoprotection, photostability, and safety evaluation

Photochemistry and Photobiology, EarlyView.
Scaffold hopping strategy used to develop chalcones structure‐related to the avobenzone tautomer. Positive aspects of 2‐hydroxychalcones are highlighted. Abstract Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters.
Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli   +11 more
wiley   +1 more source

Molecular modeling design of antitrypanosomal pyrazolone derivatives targeting Chagas disease: QSAR, docking, molecular dynamics and free energy calculations. [PDF]

J Mol Model
Sousa KKF, Barbosa ABS, Cardoso FJB, Silva JRA, Molfetta FA.   +4 more
europepmc   +1 more source

UV signature mutation hyperhotspots as genomic dosimeters

Photochemistry and Photobiology, EarlyView.
Recurrent UV signature mutations are a sensitive and specific indicator of sun exposure. UV signature mutations (C → T mutations at dipyrimidine sites) were quantified using Duplex Sequencing and a stringent mutation calling protocol to identify true low‐abundance mutations.
Vijay Menon, Alejandro García‐Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg Palmatier, Christine Ko, Kenneth Y. Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash   +12 more
wiley   +1 more source

Antimutagenic effects of a tea made from Actinidia arguta, sarunashi in Japanese, and its inhibitory effects on the formation of aberrant crypt foci induced by 1,2-dimethylhydrazine in mice. [PDF]

Genes Environ
Saiki Y, Miyake N, Arimoto-Kobayashi S.
europepmc   +1 more source

Safety assessment of the substance (2E,2'E)-2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate for use in plastic food contact materials. [PDF]

EFSA J
EFSA Panel on Food Contact Materials (FCM), Lambré C, Crebelli R, da Silva M, Grob K, Lampi E, Milana MR, Pronk M, Ščetar M, Theodoridis G, Van Hoeck E, Waegeneers N, Cariou R, Castle L, Di Consiglio E, Franz R, Barthélémy E, Comandella D, Rivière G.   +18 more
europepmc   +1 more source

Beyond Total Content: Assessing the Bioaccessibility of Metals in Tattoo Inks Using Validated Extraction Media

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT A validated analytical workflow is presented for determining total and bioaccessible concentrations of regulated elements in tattoo inks, addressing the lack of harmonized protocols for comparing extraction approaches in complex matrices. Although current legislation defines limits for soluble fractions of selected metals, it does not specify ...
Maria Luisa Astolfi, Lorenzo Zara, Arianna Antonucci, Carmela Protano   +3 more
wiley   +1 more source

Guidelines for the assessment and control of mutagenic impurities in pharmaceuticals. [PDF]

Genes Environ
Honma M.
europepmc   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, Volume 159, Issue 8, Page 1928-1936, 15 October 2026.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment. [PDF]

Regul Toxicol Pharmacol
Yauk CL, Lynch AM, Dobrovolsky VN, Schuler M, Smith-Roe SL, Fitzgerald D, Higgins J, Honarvar N, Le Curieux F, Matsumura S, Minocherhomji S, Recio L, Salk JJ, Sugiyama KI, Suzuki T, Wills JW, Marchetti F.   +16 more
europepmc   +1 more source

Nanosized Graphene‐Based Hybrid Architectures for Combating Microplastic Pollution From Water: Materials Design, Mechanisms, and Applications

Applied Research, Volume 5, Issue 5, October 2026.
Graphene hybrid architectures (GHAs) have emerged as promising materials for addressing microplastic pollution. Exceptional surface area, tunable chemistry, and synergistic functionalities play key role in GHAs. This review highlights recent advancements in GHAs for microplastic removal, emphasizing their mechanisms, efficiency, and future ...
Chirasmayee Mohanty, Rajesh Kumar Sahoo, Alaka Samal   +2 more
wiley   +1 more source