Results 221 to 230 of about 2,851,396 (315)

Investigation of Ethylene Oxide Genotoxicity Dose-Response to Inform Cancer Risk Assessment. [PDF]

Environ Mol Mutagen
Gollapudi BB, Bus JE, Cassidy P, Weinberg JT, Bemis JC, Torous DK, Dertinger SD, Lu K, Reiss R, Li AA.   +9 more
europepmc   +1 more source

Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7735-7746, October 2026.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

In Vitro Anti-Inflammatory Activity of Sour Cherry (Prunus cerasus L.) Seed Oil and Computational Safety Profiling. [PDF]

Chem Biodivers
Aydin T, Günbatan T, Berkkan A, Ulutaş OK, Sucu M.   +4 more
europepmc   +1 more source

A dual gating mechanism controls target‐strand cleavage in Cas12j: Implications for engineering efficient nickases

Protein Science, Volume 35, Issue 10, October 2026.
Abstract The rapid expansion of CRISPR technologies has unveiled a diverse repertoire of RNA‐guided endonucleases, among them the compact Cas12j, which has emerged as a promising genome‐editing tool. Cas12j cleaves the two DNA strands sequentially; however, the molecular mechanism that regulates this cleavage remains incompletely understood.
Ilias G. Karvounis, Vangelis Daskalakis
wiley   +1 more source

<i>In Vitro</i> Genotoxicity Screening and Lipid Oxidation in Pork and Chicken Burgers: Effect of Cooking and Gastrointestinal Digestion. [PDF]

Int J Mol Sci
Azqueta A, Astiasaran I, Ansorena D.
europepmc   +1 more source

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials.
Yao Wang, Junxian Zhao, Fangxia Zou, Wanglin Jiang, Jianzhao Zhang, Pengfei Yu, Liang Ye, Xiaolin Sun, Chunmei Li, Jingwei Tian   +9 more
wiley   +1 more source

Biotransformation of common NSAIDs by Cunninghamella species and resulting metabolite toxicity. [PDF]

Sci Rep
Pietrzak A, Dąbrówka B, Popiół-Adamska J, Gunia-Krzyżak A, Żelaszczyk D, Koczurkiewicz-Adamczyk P, Piska K, Żmudzki P, Pękala E, Słoczyńska K.   +9 more
europepmc   +1 more source

DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

Pest Management Science, Volume 82, Issue 10, Page 9653-9665, October 2026.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto, Stephânia Fleury Taveira   +10 more
wiley   +1 more source

Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids. [PDF]

NAM J
Seo JE, Xu HS, Revollo JR, Miranda-Colon JA, Mei N, Atrakchi AH, McGovern TJ, Davis Bruno KL, King ST, Dorsam RT, Keire DA, Kruhlak NL, Heflich RH, Guo X.   +13 more
europepmc   +1 more source

Chemical components of electric vehicle and internal combustion engine vehicle fire smoke and their mutagenic effects. [PDF]

Environ Sci Pollut Res Int
Kim YH, Nored A, Horn GP, Kesler RM, Barowy A, Schraiber A, Gaudet B, Mayer AC, Niemeier-Walsh M, Fent KW, Kovalcik K, Pancras JP, Gilmour MI.   +12 more
europepmc   +1 more source