Results 231 to 240 of about 15,527,587 (352)

Resolution of historically discordant Ames test negative/rodent carcinogenicity positive N-nitrosamines using a sensitive, OECD-aligned design. [PDF]

Mutagenesis
Thomas DN, Wills JW, Burman M, Williams AN, Harte DSG, Buckley RA, Urquhart MW, Bretonnet AS, Jeffries B, White AT, Harvey JS, Howe JR, Lynch AM.   +12 more
europepmc   +1 more source

ConforFold recovers alternative protein conformations beyond MSA subsampling

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Conformational changes underlie many aspects of protein function, yet current structure prediction tools remain limited in their ability to systematically sample structural ensembles. Here, we present ConforPSSP and ConforFold, a combined framework that integrates secondary‐structure sampling into a deep learning‐based prediction to recover ...
Raulia Syrlybaeva, Eva‐Maria Strauch
wiley   +1 more source

Safety evaluation of pectin-rich extract derived from Coffea arabica as food additive. [PDF]

EFSA J
EFSA Panel on Food Additives and Flavourings (FAF), Castle L, Andreassen M, Aquilina G, Bastos ML, Boon P, Fallico B, FitzGerald R, Frutos Fernandez MJ, Grasl-Kraupp B, Gundert-Remy U, Gürtler R, Houdeau E, Kurek M, Louro H, Morales P, Passamonti S, Barat Baviera JM, Degen G, Gott D, Leblanc JC, Moldeus P, Waalkens-Berendsen I, Wölfle D, Mech A, Tard A, Zakidou P, Ruggeri L.   +27 more
europepmc   +1 more source

Fermented Fish Products: A Comprehensive Overview of Traditional Processing Techniques, Varieties, and Their Health Benefits

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT This review addresses the processing aspects and integrates in vitro and in vivo findings to highlight the various health benefits of indigenous fermented fish products from different regions of the world. Across Asia, Africa, and Northern Europe, fermented fish holds cultural significance, with each region boasting unique varieties shaped by ...
Banlambhabok Khongthaw, Mthokozisi Dladla, Pankaj Kumar Chauhan, Kanika Dulta, Vinod Kumar, Helen Oneyaka, Soumya Ghosh   +6 more
wiley   +1 more source

Profiling biological effects of microbiome metabolites via machine learning. [PDF]

iScience
Chung HA, Fralish Z, Tu T, Reker D.
europepmc   +1 more source

Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues

Cell Proliferation, Volume 59, Issue 5, May 2026.
AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu, Ying Zhang, Wei Li   +11 more
wiley   +1 more source

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

In vivo and in vitro genotoxicity of N-nitrosopyrrolidine following UVA irradiation. [PDF]

Genes Environ
Hanaki Y, Arimoto-Kobayashi S.
europepmc   +1 more source

Discovery and Evaluation of Cadmium‐Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium‐Induced Mutations

Molecular Ecology, Volume 35, Issue 9, May 2026.
ABSTRACT Exposure to chemical pollutants can alter the rate and genome‐wide distribution of germline mutations. However, studies measuring the effects of chemical exposure on mutation rates and spectra have not considered the ecological and evolutionary backgrounds of the studied genotypes, which could influence the rates and patterns of germline ...
Nathan Keith, Stephen P. Glaholt, Craig E. Jackson, Kim Young, Karel De Schamphelaere, John K. Colbourne, Joseph R. Shaw   +6 more
wiley   +1 more source

Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis. [PDF]

Arch Toxicol
Simon S, Schlingemann J, Johnson G, Brenneis C, Guessregen B, Kostal J, Dieckhoff J.   +6 more
europepmc   +1 more source