Results 251 to 260 of about 10,959 (312)
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Mutagenicity tests with griseofulvin
Mutation Research/Genetic Toxicology, 1979Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
Leonard, A +4 more
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Mutagenicity testing in industry
Archives of Toxicology, 1977The aims of authorities, university and industrial scientists are outlined. The prime feature remains: How important are the achieved results for estimating the mutagenic risk to humans? The various methods available for the testing of chemical substances for mutagenicity are compared.
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Mutagenicity testing with Salmonella microsome test
Archives of Toxicology, 1980This in vitro mutagenicity test system comprises five different strains of S. typhimurium as target cells with the rat liver S-9 fraction and appropriate co-factors for metabolic activation of the chemical tested. The bacterial tester strains detect both mutations induced by base pair substitutions and intercalation (frame shift mutations).
Greim, H.A. +3 more
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A Test for Mutagenicity of Methylcholanthrene
Nature, 1948RECENT results by Strong1,2 and by Carr3 on mice, and by Demerec4 on Drosophila, have focused interest on a possible connexion between mutagenicity and carcinogenicity, which in the past has often been claimed on theoretical grounds. While Auerbach5 failed to produce mutations by injection of 1 : 2 : 5 : 6 dibenzanthracene into Drosophila, Demerec ...
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1985
This article deals primarily with the practical aspects of mutagen testing with yeast. Equipment necessary for a laboratory where mutagen testing with yeast is performed, and the most commonly used media, are listed. Some general procedures are described and, finally, for those who have little experience with work of this kind, a precise protocol is ...
F, Eckardt, W, Siede
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This article deals primarily with the practical aspects of mutagen testing with yeast. Equipment necessary for a laboratory where mutagen testing with yeast is performed, and the most commonly used media, are listed. Some general procedures are described and, finally, for those who have little experience with work of this kind, a precise protocol is ...
F, Eckardt, W, Siede
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Small numbers in mutagenicity tests
Archives of Toxicology, 1977Experimental control material for statistical analysis of the results of the micronuclei test in the mouse (NMRI strain) and the Chinese hamster and for the host-mediated assay in the mouse (NMRI strain) using auxotrophic bacterial strains are presented. The binomial distribution of the micronuclei makes it possible to analyse the sample size according
A, Grafe, J, Vollmar
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Mutagenicity testing with Drosophila
Archives of Toxicology, 1980The fruit fly, Drosophila melanogaster with its well known genetics is used to detect newly induced mutations in germ cells. Assay systems are available to determine point mutations, chromosome aberrations and nondisjunction. The sex-linked recessive lethal test is of primary practical importance, because it can detect mutagens with and without ...
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A test for mutagenicity of caffeine in mice
Zeitschrift für Vererbungslehre, 19621. The results are given of an experiment comparing the specific locus mutation-rates in male and in female mice having 0.1% caffeine dissolved in their drinking-water up to the age of ten weeks. Their parents had the same treatment from the time of mating, so that the tested germ-cells might be exposed to caffeine during embryonic development.
Lyon, M F, Phillips, R J, Searle, A G
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Assessment of Mutagenicity Tests
1980Using the short term tests it is possible to evaluate whether or not chemicals are potential mutagens. The mutagenic hazards for man, however, have to be established by tests on mammals in vivo. Where reproducible mutagenicity findings exist with conclusive tests, consideration of the possible threshold doses, together with benefit/risk equations ...
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Journal of Toxicology and Environmental Health, 1980
The universality of the genetic system in living organisms and the high experimental correlation between mutagenicity and carcinogenicity provide the rational basis for the use of mutagenicity in screening of possible carcinogens. The present genetic methodologies using microorganisms, cell cultures, Drosophila, and rodents are evaluated.
C, Ramel, U, Rannug
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The universality of the genetic system in living organisms and the high experimental correlation between mutagenicity and carcinogenicity provide the rational basis for the use of mutagenicity in screening of possible carcinogens. The present genetic methodologies using microorganisms, cell cultures, Drosophila, and rodents are evaluated.
C, Ramel, U, Rannug
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