Results 261 to 270 of about 10,959 (312)
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Mutagenicity tests with cadmium in the mouse
Toxicology, 1975The testicle is known to be the critical organ in acute exposure of experimental mammals to cadmium. Such treatment results in temporary sterility and, very often, in the appearance of testicular interstitial cell tumors. The present experiments were performed to determine whether such deleterious effects on the male reproductive organs involved any ...
Gilliavod, N, Leonard, A
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1985
The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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Mutagenicity Testing with Drosophila Melanogaster
1985The fruit fly, Drosophila melanogaster, is the eukaryote most often used to detect mutations in germ cells. There are several facts which make this insect an attractive test system for screening chemical compounds for mutagenic activity. The short generation time of only 10 days, low cost of culture media, easy breeding of large numbers of animals with
F E, Würgler, U, Graf
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Microorganisms as test systems for mutagenicity
Archiv f�r Toxikologie, 1971The mutagenic activity of different compounds in bacterial mutagenicity test systems has been investigated. The systems used include back-mutations to prototrophy in auxotrophic strains of Serratia marcescens and forward mutations to galactose prototrophy in a phenotypic galactose negative strain of Escherichia coli.
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Mutagenicity testing with eukaryotic microorganisms
Archives of Toxicology, 1980The different genetic end-points which can be tested to detect genotoxicity of chemicals in fungi and especially in the yeast Saccharomyces cerevisiae are described. They include reversion and forward mutation, mitochondrial deletions and point mutations, mitotic or meiotic intra- and intergenic recombination, chromosomal non-disjunction and aneuploidy.
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A combined testing protocol approach for mutagenicity testing
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979The antischistosomal agent, hycanthone methanesulfonate (HMS), was employed to illustrate the utility of carrying out several mutagenicity tests in a single concurrent animal experiment. Several commonly used procedures that were successfully integrated into a multiple testing protocol included (1) metaphase analysis in bone marrow, (2) micronucleus ...
T H, Connor +3 more
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Mutagenicity research and testing in Sweden
Mutation Research, 1975A survey is given of Swedish legislation for control of chemicals in the environment. Although no direct legal requirements for mutagenicity testing of chemicals exist at present in Sweden, such requirements can be enforced within the existing laws. Testing and research in chemical mutagenicity are especially performed at the Environmental Toxicology ...
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REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST
Mutation Research/Environmental Mutagenesis and Related Subjects, 1983The methods for detecting carcinogens and mutagens with the Salmonella mutagenicity test were described previously (Ames et al., 1975b). The present paper is a revision of the methods. Two new tester strains, a frameshift strain (TA97) and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set.
D M, Maron, B N, Ames
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Testing Chemicals for Mutagenicity in a Mammal
Nature, 1966WHILE admitting that mammals would be preferable to diptera for testing newly introduced drugs for possible genetic (that is, mutagenic) effects, Prof. Luning1 argues that tests with mice would be expensive and time consuming and therefore advocates the use of Drosophila larvae grown on medium containing the drug, which are then tested for chromosome ...
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Cytogenetic techniques in mutagenicity testing
Agents and Actions, 1973Both in vivo and in vitro methodologies have uses as cytogenetic test systems for mutagenicity testing. The in vivo methods are certainly the choice as the primary test system, except perhaps in the case of viruses and some biologicals. When an in vitro method is used anaphase offers some advantages as greater speed and ease of observation, the ...
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