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Mutagenicity testing with eukaryotic microorganisms
Archives of Toxicology, 1980The different genetic end-points which can be tested to detect genotoxicity of chemicals in fungi and especially in the yeast Saccharomyces cerevisiae are described. They include reversion and forward mutation, mitochondrial deletions and point mutations, mitotic or meiotic intra- and intergenic recombination, chromosomal non-disjunction and aneuploidy.
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Assessment of Mutagenicity Tests
1980Using the short term tests it is possible to evaluate whether or not chemicals are potential mutagens. The mutagenic hazards for man, however, have to be established by tests on mammals in vivo. Where reproducible mutagenicity findings exist with conclusive tests, consideration of the possible threshold doses, together with benefit/risk equations ...
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A combined testing protocol approach for mutagenicity testing
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979The antischistosomal agent, hycanthone methanesulfonate (HMS), was employed to illustrate the utility of carrying out several mutagenicity tests in a single concurrent animal experiment. Several commonly used procedures that were successfully integrated into a multiple testing protocol included (1) metaphase analysis in bone marrow, (2) micronucleus ...
T H, Connor +3 more
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Mutagenicity testing of some medicinal herbs
Journal of Ethnopharmacology, 1987AbstractExtracts of four brands of a Pakistani local medicine called naswar and six indigenous herbs commonly used as medicine in children were tested for their ability to induce mutations to prototrophy in Salmonella typhimurium tester strains TA98, TA100, TA1535, and TA1537.
S, Riazuddin, M M, Malik, A, Nasim
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1985
The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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Cytogenetic techniques in mutagenicity testing
Agents and Actions, 1973Both in vivo and in vitro methodologies have uses as cytogenetic test systems for mutagenicity testing. The in vivo methods are certainly the choice as the primary test system, except perhaps in the case of viruses and some biologicals. When an in vitro method is used anaphase offers some advantages as greater speed and ease of observation, the ...
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Statistical problems in mutagenicity tests
Archives of Toxicology, 1977Everyone involved in planning and carrying out biological experiments has to concern himself with statistical methods. Thus, descriptive statistics (e. g. calculation of the mean) help to present results briefly and comprehensively and, in addition, statistical test procedures permit decisions to be made even in an uncertain situation.
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Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals.
Environmental Mutagenesis, 1986K. Mortelmans +5 more
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Bacterial Mutagenicity Assays: Test Methods
2011The most widely used assays for detecting chemically induced gene mutations are those employing bacteria. The plate incorporation assay using various Salmonella typhimurium LT2 and E. coli WP2 strains is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances capable of causing DNA damage ...
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Whole-mammal mutagenicity tests: evaluation of five methods.
Mutation research, 1980L. B. Russell, B. Matter
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