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Testing Chemicals for Mutagenicity in a Mammal
Nature, 1966WHILE admitting that mammals would be preferable to diptera for testing newly introduced drugs for possible genetic (that is, mutagenic) effects, Prof. Luning1 argues that tests with mice would be expensive and time consuming and therefore advocates the use of Drosophila larvae grown on medium containing the drug, which are then tested for chromosome ...
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REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST
Mutation Research/Environmental Mutagenesis and Related Subjects, 1983The methods for detecting carcinogens and mutagens with the Salmonella mutagenicity test were described previously (Ames et al., 1975b). The present paper is a revision of the methods. Two new tester strains, a frameshift strain (TA97) and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set.
D M, Maron, B N, Ames
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Mutagenicity testing on ethylenethiourea
Mutation Research, 1977Abstract A potential mutagenicity of ethylenethiourea (ETU) was investigated by a series of experiments including microbial, cytogenetic and dominant-lethal studies. The microbial studies revealed a weak mutagenic activity of ETU for Salmonella strain TA1535.
S. Teramoto +6 more
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Cytogenetic techniques in mutagenicity testing
Agents and Actions, 1973Both in vivo and in vitro methodologies have uses as cytogenetic test systems for mutagenicity testing. The in vivo methods are certainly the choice as the primary test system, except perhaps in the case of viruses and some biologicals. When an in vitro method is used anaphase offers some advantages as greater speed and ease of observation, the ...
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Statistical problems in mutagenicity tests
Archives of Toxicology, 1977Everyone involved in planning and carrying out biological experiments has to concern himself with statistical methods. Thus, descriptive statistics (e. g. calculation of the mean) help to present results briefly and comprehensively and, in addition, statistical test procedures permit decisions to be made even in an uncertain situation.
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Mutagen Testing with the Soybean Assay
1985The soybean (Glycine max) system tests for induction of somatic mosaicism on the leaves. This mosaicism results from genetic changes induced by the agent in question in one or more cells which are rapidly dividing. Any type of mosaicism which results in a phenotypically distinct marker can be used.
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Extrapolation of Mutagenicity Testing to the Human
1982Agricultural genetic toxicology is typical of the challenging problems now being encountered in the rapidly growing field of environmental mutagenesis. Both fields involve a rich diversity of important chemicals, some already known mutagens, a few known carcinogens; both have some hints of human toxicity, but by and large no concrete human data; and ...
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