Results 51 to 60 of about 13,277,354 (332)

Mutagenicity and Acute Oral Toxicity Test for Herbal Poultry Feed Supplements

Journal of Toxicology, 2018
Herbal products are being used and trusted globally for thousands of years for their health benefits and limited side effects. Globally, a general belief amongst the consumers is that herbal supplements are always safe because they are “natural.” But ...
Boddapati Srinivasa Rao, C. V. Chandrasekaran, H. S. Srikanth, Murugan Sasikumar, R. Edwin Jothie, Begum Haseena, Bethapudi Bharathi, Ramasamy Selvam, D’Souza Prashanth   +8 more
doaj   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Study of acute and subacute toxicities and genotoxic and mutagenic potentials of the lyophilized extract of Campomanesia sessiliflora (O.Berg) mattos leaves in wistar rats

Bioscience Journal
Campomanesia sessiliflora (O.Berg) Mattos is a Brazilian native plant species used in a popular medicinal tea for treating gastrointestinal, urinary, and dermatological pathologies.
Anahy Arruda Burigato, Jacenir Vieira da Silva, Larissa Pires Mueller, Flávio Henrique Souza de Araújo, Cláudia Andréa Lima Cardoso, Roosevelt Isaías Carvalho Souza, Agruslávia Rezende de Souza, Felipe Francisco Bittencourt Junior, Silvia Aparecida Oesterreich   +8 more
doaj   +1 more source

MUTAGENICITY TEST OF HALOPREDONE ACETATE

The Journal of Toxicological Sciences, 1985
The mutagenicity of halopredone acetate (THS-201) was investigated by means of reverse mutation test in seven bacterial strains (S. typhimurium TA100, TA1535, TA98, TA1538, TA1537 and E. coli WP2, WP2 uvrA) and chromosomal aberration test in cultured Chinese hamster cells (CHL).
Ken'ichi Morita, Ryoichi Yoshida, Akinobu Ohuchida   +2 more
openaire   +4 more sources

Potential‐Driven Dynamic Spring‐Effect of Pd─Cu Dual‐Atoms Empowered Stability and Activity for Electrocatalytic Reduction

Advanced Science, EarlyView.
The dynamic “spring‐like” behavior of Pd─Cu dual atoms with PdN3─CuN3 coordination structure can be stretched and recovered with potential variation, which remarkably elevates the structural stability and catalytic activity of Cu atoms for electrocatalytic reduction reactions in strong‐acid electrolytes. The modulated electron‐orbit coupling effect and
Pei‐Hua Li, Yuan‐Fan Yang, Zong‐Yin Song, Bo Liang, Yong‐Huan Zhao, Xin Cai, Zi‐Hao Liu, Jing‐Yi Lin, Meng Yang, Xiangyu Xiao, Jing Zhang, Wen‐Qing Liu, Xing‐Jiu Huang   +12 more
wiley   +1 more source

Genotoxicity evaluation of magnesium salts of isobutyrate and 2-methylbutyrate

Toxicology Reports, 2021
Results of genotoxicity studies for magnesium salts of isobutyrate and 2-methylbutyrate, two candidate ingredients for inclusion in animal feed, are described in this manuscript.
Laurie C. Dolan, Paola Ciliutti, Laura Bisini, Cristina Marabottini, Brian Curtin   +4 more
doaj  

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

Advanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li, Huiqin Chen, Qiaofeng Shen, Yingshuang Liu, Pingping Li, Yuqi Ma, Yugang Wang, Shengkai Li, Xueqing Yan, Liyu Liu, Jianwei Shuai, Min Wu, Qi Ouyang, Feng‐Ming (Spring) Kong, Gen Yang   +14 more
wiley   +1 more source

Genotoxicity and mutagenicity assessment of a standardized extract (P2Et) obtained from Caesalpinia spinosa

Toxicology Reports, 2021
The standardized P2Et extract obtained from Caesalpinia spinosa has shown antioxidant, and direct antitumor activity, but also activation of specific immune response through the induction of tumor immunogenic cell death in breast and melanoma cancer ...
R. Ballesteros-Ramírez, M.I. Durán, S. Fiorentino   +2 more
doaj  

PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes

Angewandte Chemie International Edition, Accepted Article.
Site‐directed mutagenesis (SDM) is a key driver for many biochemical investigations and biotechnological applications. Despite decades of development, it is still difficult to perform SDM on some sequences, including highly repetitive ones, because polymerase chain reaction (PCR) is often used as the most effective method for SDM, but results in ...
Mingkuan Lyu, Linggen Kong, Xiangli Shao, Yi Lu   +3 more
wiley   +1 more source

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source