Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept®, Roche): overview [PDF]
AIDS Research and Therapy, 2009 Roche's protease inhibitor nelfinavir mesylate (Viracept®) produced between March 2007-June 2007 was found to contain elevated levels of ethyl methanesulfonate (EMS), a known mutagen (alkylator) – leading to a global recall of the drug.
Jones Judith K +5 more
doaj +4 more sources
In vivo mutagenicity assessment of styrene in MutaMouse liver and lung
Genes and Environment, 2023 Background Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a small amount of styrene transferred ...
Yasumasa Murata +10 more
doaj +1 more source
BMC Genomics, 2022 Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to analyze mutation induction across twenty 2.4 kb intergenic and genic targets ...
Danielle P. M. LeBlanc +8 more
doaj +1 more source
Genes and Environment, 2023 Background tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester.
Yasumasa Murata +10 more
doaj +1 more source
Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo [PDF]
, 2013 Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. Although HR is mostly error free, inherent or environmental conditions that either suppress or induce HR cause genomic instability. Despite its
Chow, Danielle N. +16 more
core +7 more sources
The immobilization of polyethylene imine nano and microspheres on glass using high intensity ultrasound [PDF]
, 2013 The present article describes the creation and immobilization of Polyethylene imine (PEI) capsules on a glass surface. The synthesis and deposition were accomplished by short-time (3 min) one-step reaction.
Gedanken, Aharon +2 more
core +1 more source
Pro-inflammatory and toxicological evaluation of Hepacare in mice [PDF]
, 2017 Objectives: Hepacare! is a widely marketed herbal formulation in Nigeria for treating chronic liver ailments. This study evaluated the safety, as well as pro- inflammatory and genotoxicity effects, of Hepacare! in mice.
Adebayo, H. A. +3 more
core +2 more sources
Multi-walled carbon nanotube-induced genotoxic, inflammatory and pro-fibrotic responses in mice: Investigating the mechanisms of pulmonary carcinogenesis [PDF]
, 2017 The International Agency for Research on Cancer has classified one type of multi-walled carbon nanotubes (MWCNTs) as possibly carcinogenic to humans. However, the underlying mechanisms of MWCNT- induced carcinogenicity are not known.
Aziz, Syed Abdul +9 more
core +2 more sources
A trial of somatic gene targeting in vivo with an adenovirus vector [PDF]
, 2005 BACKGROUND: Gene targeting in vivo provides a potentially powerful method for gene analysis and gene therapy. In order to sensitively detect and accurately measure designed sequence changes, we have used a transgenic mouse system, MutaMouse, which has ...
Handa, Naofumi +5 more
core +2 more sources
Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures [PDF]
, 2023 Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in vivo-like characteristics than 2D monocultures.
Al-Serori, Halh +15 more
core +2 more sources