Results 51 to 60 of about 291 (106)

Re‐assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials

EFSA Journal, Volume 23, Issue 6, June 2025.
Abstract The EFSA Panel on Food Contact Materials (FCM) was requested by the European Commission to re‐evaluate the potential genotoxicity of styrene after oral exposure and its safety for use in plastic FCM with a specific migration limit (SML) of 40 μg/kg food.
EFSA Panel on Food Contact Materials (FCM), Claude Lambré, Riccardo Crebelli, Maria Da Silva, Konrad Grob, Evgenia Lampi, Maria Rosaria Milana, Marja Pronk, Mario Ščetar, Georgios Theodoridis, Els Van Hoeck, Nadia Waegeneers, Claudia Bolognesi, Emma Di Consiglio, Marcel Mengelers, Zainab Al Harraq, Irene Muñoz Pilar, Sandra Rainieri, Gilles Rivière   +18 more
wiley   +1 more source

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model [PDF]

, 2010
TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that they may provide clues to the identity of the causative mutagenic agent.
Arlt, Volker M., Kucab, Jill E., Phillips, David   +2 more
core   +2 more sources

Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig‐a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells [PDF]

Environmental and Molecular Mutagenesis, 2019
Procarbazine hydrochloride (PCH) is a DNA‐reactive hematopoietic carcinogen with potent and well‐characterized clastogenic activity. However, there is a paucity of in vivo mutagenesis data for PCH, and in vitro assays often fail to detect the genotoxic effects of PCH due to the complexity of its metabolic activation. We comprehensively evaluated the in
Clotilde Maurice, Stephen D. Dertinger, Carole L. Yauk, Francesco Marchetti   +3 more
openaire   +2 more sources

Investigation of mutagenicity of styrene in tumor target and non‐target tissues of transgenic Big Blue® mice

Environmental and Molecular Mutagenesis, Volume 66, Issue 1-2, Page 34-44, January-February 2025.
Abstract Styrene has been shown to induce lung tumors in mice, but not in rats. The current study investigated the potential role of genotoxicity as an initial key event in the mode of action for styrene‐induced lung tumors in mice. Transgenic male B6C3F1 Big Blue® mice were treated by oral gavage for 28 consecutive days with 0 (corn oil), 75, 150, or ...
B. Bhaskar Gollapudi, Karen Philp, Jeffrey T. Weinberg   +2 more
wiley   +1 more source

Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis [PDF]

N-nitroso-bisoprolol (NBP) is a nitrosamine drug substance-related impurity (NDSRI) of bisoprolol, which is used to treat cardiac diseases since decades. To investigate the mutagenic potential of NBP, in vitro methods such as Enhanced Ames Test (EAT) and
George Johnson
core   +1 more source

Re‐evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow‐up of its re‐evaluation as a food additive for uses in foods for all population groups

EFSA Journal, Volume 22, Issue 10, October 2024.
Abstract The present opinion is the follow‐up of the conclusions and recommendations of the Scientific Opinion on the re‐evaluation of silicon dioxide (E 551) as a food additive relevant to the safety assessment for all age groups. In addition, the risk assessment of silicon dioxide (E 551) for its use in food for infants below 16 weeks of age is ...
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Cristina Andreoli, Maria Bastos, Diane Benford, Margherita Bignami, Claudia Bolognesi, Karlien Cheyns, Emanuela Corsini, Riccardo Crebelli, Birgit Dusemund, Rex Fitzgerald, Eric Gaffet, Katrin Loeschner, Francesca Marcon, Jan Mast, Manuela Mirat, Alicja Mortensen, Agnes Oomen, Josef Schlatter, Dominique Turck, Beate Ulbrich, Anna Undas, Christiane Vleminckx, Detlef Woelfle, Ruud Woutersen, Stefania Barmaz, Borana Dino, Gabriele Gagliardi, Sara Levorato, Elena Mazzoli, Alexis Nathanail, Ana Maria Rincon, Laura Ruggeri, Camilla Smeraldi, Alexandra Tard, Sam Vermeiren, Ursula Gundert‐Remy   +53 more
wiley   +1 more source

Protocol for risk assessment of “other substances”. The Norwegian Scientific Committee for Food and Environment [PDF]

, 2020
publishedVersio
Alexander, Jan, Bodin, Johanna Eva, Caspersen, Ida Henriette, Duale, Nur, Krogdahl, Åshild, Mathisen, Gro Haarklou, Sanden, Monica, Svendsen, Camilla, Ørnsrud, Robin   +8 more
core   +4 more sources

Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone [PDF]

, 2017
The frequency of stable DNA adducts in a target tissue can be used to assess biologically effective dose; however, the utility of the metric in a risk assessment context depends on the likelihood that the DNA damage will be manifested as mutation ...
Arlt, Volker M, Douglas, George R, Phillips, David H, White, Paul A   +3 more
core   +2 more sources

Assessing the genotoxicity of N‐nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild‐type C57BL/6N mice

Environmental and Molecular Mutagenesis, Volume 65, Issue 6-7, Page 190-202, July‐August 2024.
Abstract The detection of N‐nitrosamines in drug products has raised global regulatory interest in recent years due to the carcinogenic potential of some nitrosamines in animals and a need to identify a testing strategy has emerged. Ideally, methods used would allow for the use of quantitative analysis of dose–response data from in vivo genotoxicity ...
Shaofei Zhang, Stephanie L. Coffing, William C. Gunther, Michael L. Homiski, Richard A. Spellman, Phu Van, Maik Schuler   +6 more
wiley   +1 more source

Statistical analysis of lacZ mutant frequency data from Muta^TMMouse mutagenicity assays [PDF]

Mutagenesis, 1998
Transgenic mouse assays have provided an unprecedented opportunity to study mutagenesis in diverse rodent tissues. In this article data from MutaMouse mutagenicity assays based on the Escherichia coli gene lacZ were analyzed systematically using liver and bone marrow as potential target tissues.
K Y, Fung, G R, Douglas, D, Krewski
openaire   +2 more sources