Results 71 to 80 of about 291 (106)

Temporal analyses of germ cell mutations using the MutaMouse model support the recommended design in OECD test guideline 488

Archives of Toxicology
Abstract The Organisation for Economic Co-operation and Development test guideline (TG) 488 uses transgenic rodent models to assess in vivo mutagenesis. TG 488 recommends 28 consecutive days of exposure with sampling of germ cells from seminiferous tubules 28 days post-exposure (i.e., 28 + 28d).
Gu Zhou, Andrew Williams, Danielle P. M. LeBlanc, George R. Douglas, Carole L. Yauk, Francesco Marchetti   +5 more
openaire   +2 more sources

Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver [PDF]

, 2011
The liver plays a pivotal role in the metabolism of nutrients, drugs, hormones, and metabolic waste products, thereby maintaining body homeostasis. The liver undergoes substantial changes in structure and function within old age.
Bohr, Vilhelm A., de Souza-Pinto, Nadja C., Lebel, Michel   +2 more
core   +3 more sources

Expression of Progerin does not result in an increased mutation rate. [PDF]

, 2017
In the premature ageing disease Hutchinson-Gilford progeria syndrome (HGPS), the underlying genetic defect in the lamin A gene leads to accumulation at the nuclear lamina of progerin—a mutant form of lamin A that cannot be correctly processed.
A Ino, A Rapp, AK Agarwal, B Liu, B Liu, BA Kudlow, BC Myhr, C Morey, Charlene Lemaître, CL Navarro, DA Barbie, DK Shumaker, DP Turner, E Gazave, EJ Mientjes, Emmanuelle Deniaud, G Viteri, GA Garinis, GM Martin, GW Intano, IS Mehta, J Boyle, JA Gossen, JA Gossen, K Cao, K Manju, LJ Niedernhofer, M Eriksson, ME Dolle, ME Dolle, MO Bergo, OA Sedelnikova, P Scaffidi, PA White, PR Musich, PS Shwed, RA Busuttil, RA Busuttil, RD Goldman, RP McCord, S Ghosh, S Gilchrist, S Gonzalo, SA Richards, SH Yang, Shelagh Boyle, SW Wijnhoven, SW Wijnhoven, T Dechat, T Dechat, T Misteli, TC Hsu, V Gorbunova, W Li, Wendy A. Bickmore, Y Liu, Y Liu, Z Guo   +57 more
core   +1 more source

Evaluation of the cytotoxicity and genotoxicity of aristolochic acid I - A component of Aristolochiaceae plant extracts used in homeopathy [PDF]

, 2013
The medicinal plants Aristolochia clematitis L. as well as Asarum europaeum L., representatives of the plant family Aristolochiaceae and mentioned in the German Homeopathic Pharmacopeia, contain aristolochic acid. We found that the mother tinctures of A.
Arlt, Volker M, Melzig, Matthias F, Nitzsche, Dana   +2 more
core   +2 more sources

Risk assessment of hesperidin – “other substances” [PDF]

Hesperidin utgjør ingen helserisiko Det er trygt å bruke hesperidin i kosttilskudd. Det er konklusjonen fra en risikovurdering utført av Vitenskapskomiteen for mat og miljø (VKM).
Boahene, Nana Yaa, Bodin, Johanna Eva, Hofer, Tim, Müller, Mette Helen Bjørge, Parr, Christine Louise   +4 more
core   +3 more sources

The mutagenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in Muta (TM) Mouse colon is attenuated by resveratrol [PDF]

, 2014
Barrett, Bertelli, Boobis, Boyce, Buonarati, Chun, Davis, Dean, Donovan, Edwards, Fahey, Felton, Ferrucci, Fu, Gooderham, Lamuela-Raventos, Lauber, Layton, Lynch, Mientjes, Murray, Rich, Rotches-Ribalta, Schneider, Siemann, Stuart, Tan, Tessitore, Uenobe, Ushijima, Yadollahi-Farsani, Yang, Yoshimi, Zhang, Zhao   +34 more
core   +1 more source

DNA Repair and Mutagenesis of ADP-Ribosylated DNA by Pierisin [PDF]

Toxins.
29763, 70332963, Kawanishi, Masanobu, Totsuka, Yukari, Wakabayashi, Keiji, Yagi, Takashi, 川西, 優喜   +6 more
core   +1 more source

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment [PDF]

, 2014
George Johnson, Owen Bodger
core   +1 more source

New approaches to advance the use of genetic toxicology analyses for human health risk assessment [PDF]

, 2014
George Johnson, Shareen Doak
core   +1 more source

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay [PDF]

There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment.
Luker, George W.
core   +1 more source