Results 41 to 50 of about 2,913,254 (384)
Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens
Nature, 2014 The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor ...
M. Gubin +26 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source
Cell Death and DiseaseOverexpression of mitotic arrest deficiency 2 (MAD2/MAD2L1), a pivotal component of the spindle assembly checkpoint (SAC), resulted in many types of cancer.
Yao Xi +14 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk +9 more
wiley +1 more source
Forward Genetics by Sequencing EMS Variation-Induced Inbred Lines
G3: Genes, Genomes, Genetics, 2017 In order to leverage novel sequencing techniques for cloning genes in eukaryotic organisms with complex genomes, the false positive rate of variant discovery must be controlled for by experimental design and informatics.
Charles Addo-Quaye +5 more
doaj +1 more source
Influence of UV light exposure on mineral composition and biomass production of mycomeat produced from different agricultural substrates [PDF]
Journal of Agricultural Sciences (Belgrade), 2017 The wild and mutant strain of Pleurotus sajor caju was cultured on different agricultural substrates. Treatment 1 contained agricultural substrates alone. Treatment 2 contained the mutant strain of the mushroom plus agricultural waste. Treatment
Adejumo Isaac Oluseun +2 more
doaj +1 more source
Drosophila melanogaster mutant tan [PDF]
, 2009 Drosophila melanogaster gene tan was originally discovered in the early 20th century as a mutant strain lacking the dark pi gment pattern of wild-type (wt) f lies and, therefore, showing a light yellowish brown color (McEwen, 1918 ...
Badaracco, Alejandra +2 more
core
Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]
, 2017 The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R. +4 more
core +2 more sources
Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
Cancer Cell, 2014 Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that ...
P. Muller, K. Vousden
semanticscholar +1 more source
Mutant knots and intersection graphs [PDF]
, 2007 We prove that if a finite order knot invariant does not distinguish mutant knots, then the corresponding weight system depends on the intersection graph of a chord diagram rather than on the diagram itself.
Chmutov +9 more
core +3 more sources