Results 41 to 50 of about 2,692,923 (420)
Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]
, 2018 Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong +4 more
core +2 more sources
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.
New England Journal of Medicine, 2016 We identified a polyclonal CD8+ T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a patient with metastatic colorectal cancer.
E. Tran +11 more
semanticscholar +1 more source
Unbalanced overexpression of the mutant allele in murine Patched mutants [PDF]
Carcinogenesis, 2002 Inherited mutations of Patched (PTCH) in the nevoid basal cell carcinoma syndrome (NBCCS) lead to several developmental defects and contribute to tumor formation in a variety of tissues. PTCH mutations have been also identified in sporadic tumors associated with NBCCS including basal cell carcinoma (BCC) and medulloblastoma.
Calzada-Wack, J. +8 more
openaire +5 more sources
Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes [PDF]
, 2017 Rhodopseudomonas palustris is a species of purple photosynthetic bacteria that has a multigene family of puc genes that encode the alpha and beta apoproteins, which form the LH2 complexes.
Carey, Anne-Marie +8 more
core +1 more source
Pharmacological Research, 2023 Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie +18 more
doaj
The EuroBiotech Journal, 2022 Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice.
Brown Richard E.
doaj +1 more source
Vulnerability Mimicking Mutants [PDF]
arXiv, 2023 With the increasing release of powerful language models trained on large code corpus (e.g. CodeBERT was trained on 6.4 million programs), a new family of mutation testing tools has arisen with the promise to generate more "natural" mutants in the sense that the mutated code aims at following the implicit rules and coding conventions typically produced ...
arxiv
Isolation of segmented filamentous bacteria from complex gut microbiota
BioTechniques, 2015 Segmented filamentous bacteria (SFB) modulate the ontogeny of the immune system, and their presence can significantly affect mouse models of disease. Until recently, the inability to successfully culture SFB has made controlled studies on the mechanisms ...
Aaron C. Ericsson +7 more
doaj +1 more source
Mutant phenotypes for thousands of bacterial genes of unknown function
Nature, 2018 One-third of all protein-coding genes from bacterial genomes cannot be annotated with a function. Here, to investigate the functions of these genes, we present genome-wide mutant fitness data from 32 diverse bacteria across dozens of growth conditions ...
M. Price +24 more
semanticscholar +1 more source
Journal of Social Intervention: Theory and Practice, 2016 Ed de Jonge. Beelden van de Professional. Inspiratiebronnen voor professionalisering. Delft: Eburon, 2015, 409 p., €35,00.
Fuusje de Graaff
doaj +1 more source