Results 41 to 50 of about 4,183,748 (324)

Abstention électorale à Madagascar : entre déficit civique et défaillance de la classe politique [PDF]

Mouvements et Enjeux Sociaux, 2022
Longtemps ignorée par les chercheurs en sciences sociales, l’abstention électorale devient une des problématiques majeures de la démocratie représentative en ce moment. Tel est également le cas pour Madagascar.
Jean Angelson RANDRIAMBOAVONJY
doaj  

Fast Genetic Algorithms

, 2017
For genetic algorithms using a bit-string representation of length~$n$, the general recommendation is to take $1/n$ as mutation rate. In this work, we discuss whether this is really justified for multimodal functions. Taking jump functions and the $(1+1)$
Doerr, Benjamin, Le, Huu Phuoc, Makhmara, Régis, Nguyen, Ta Duy   +3 more
core   +1 more source

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay [PDF]

, 2017
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers).
Baert, Annelot, Claes, Kathleen, De Leeneer, Kim, De Nobele, Sylvia, Depuydt, Julie, Malfait, Fransiska, Perletti, Gianpaolo, Poppe, Bruce, Van Damme, Tim, Van Maerken, Tom, Vral, Anne   +10 more
core   +1 more source

Synthesis and properties of a glyphosate isopropylamine salt slow-release agent via γ-ray irradiation

Fushe yanjiu yu fushe gongyi xuebao
To improve the rate of pesticide utilization, reduce pesticide usage, and effectively eliminate the adverse effects of pesticides on the environment, a carrier material was prepared by modifying starch using a one-step irradiation treatment. This carrier
LIU Lu, ZHANG Leping, XIE Hongke, WU Jing, WU Xiaofen, GUO Feng, ZHAO Caifeng, SHAO Sai   +7 more
doaj   +1 more source

A practical guide for mutational signature analysis in hematological malignancies

Nature Communications, 2019
Mutational signature analysis provides important information about the mutational processes underpinning different stages of tumorigenesis. Here, the authors compare publicly available signature extraction tools and suggest a framework for the generation
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S. Puente, Herve Avet-Loiseau, Peter J. Campbell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli   +14 more
doaj   +1 more source

Gamma Rays and Sodium Azide Induced Genetic Variability in High-Yielding and Biofortified Mutant Lines in Cowpea [Vigna unguiculata (L.) Walp.]

Frontiers in Plant Science, 2022
With the twin pressures of high population growth and extreme weather events, developing countries are the worst hit in meeting the food demands of their people, with millions unable to access adequate and nutritionally balanced food.
Aamir Raina, Aamir Raina, Rafiul Amin Laskar, Mohammad Rafiq Wani, Basit Latief Jan, Sajad Ali, Samiullah Khan   +6 more
doaj   +1 more source

Semantic mutation testing [PDF]

, 2010
This is the Pre-print version of the Article. The official published version can be obtained from the link below - Copyright @ 2011 ElsevierMutation testing is a powerful and flexible test technique.
Barnes, Baudry, Black, Bottaci, Brilliant, Cordy, DeMillo, Do, Fabbri, Fabbri, Frankl, Gosling, Haitao Dan, Hamlet, Harel, Harel, Harman, Hatton, Hierons, Howden, John A. Clark, King, Mathur, Offutt, Offutt, Offutt, Offutt, Offutt, Offutt, Offutt, Offutt, Robert M. Hierons, Sidhu, Stroustrup, Voas, von der Beeck, Wah, Woodward   +37 more
core   +1 more source

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

New England Journal of Medicine, 2009
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers of a BRCA1 or ...
P. Fong, D. Boss, T. Yap, A. Tutt, P. Wu, M. Mergui-Roelvink, Peter S. Mortimer, H. Swaisland, A. Lau, M. O’Connor, A. Ashworth, J. Carmichael, S. Kaye, J. Schellens, J. D. de Bono   +14 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S, Gou, Liangke, Kruglyak, Leonid   +2 more
core   +1 more source