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Efficiency of carcinogenesis with and without a mutator mutation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2006 Carcinogenesis involves the acquisition of multiple genetic changes altering various cellular phenotypes. These changes occur within the fixed time period of a human lifespan, and mechanisms that accelerate this process are more likely to result in clinical cancers.
Robert A Beckman +2 more
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International Journal of Computer Mathematics, 2011
We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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We propose mutation systems as a model of the evolution of a string subject to the effects of mutations and a fitness function. One fundamental question about such a system is whether knowing the rules for mutations and fitness, we can predict whether it is possible for one string to evolve into another.
Dana Angluin +2 more
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Mutation and Mutation Screening
2013Molecular techniques have created the opportunity for great advances in plant mutation genetics and the science of mutation breeding. The powerful targeted induced local lesions in genomes (TILLING) technique has introduced the possibility of reverse genetics-the ability to screen for mutations at the DNA level prior to assessing phenotype. Fundamental
Lee, L Slade +4 more
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Current Protocols in Human Genetics, 2003
AbstractAs part of the Human Genome Variation Society (formerly known as the HUGO Mutation Database Initiative), a committee was formed to suggest standards for the description of sequence variants in DNA, RNA, and protein sequences. The committee proposed that the nomenclature should be unequivocal, precise, and short, and should prevent any possible ...
den Dunnen, J. T. +1 more
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AbstractAs part of the Human Genome Variation Society (formerly known as the HUGO Mutation Database Initiative), a committee was formed to suggest standards for the description of sequence variants in DNA, RNA, and protein sequences. The committee proposed that the nomenclature should be unequivocal, precise, and short, and should prevent any possible ...
den Dunnen, J. T. +1 more
openaire +3 more sources
Software Testing, Verification and Reliability, 2001
AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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AbstractApplications that utilize a broker‐based architecture are often composed of components that need to be tested individually and in combination. Furthermore, adequacy assessment of tests of components is useful in that it assists testers in identifying weaknesses in the tests generated so far and in offering hints on what the new tests must be ...
Sudipto Ghosh 0001, Aditya P. Mathur
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Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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Characterization of the mutator mutation mut5-1
Molecular and General Genetics MGG, 1979The mutator mutation mut5-1 has been characterized with respect to a range of parameters which have been used to describe DNA repair mutants of yeast. No marked effect of the mutation on UV-mutability at lower doses was apparent. Diploids homozygous for the mutation are deficient in UV-induced recombination between the alleles his1-1 and hist1-315 ...
D P, Morrison, P J, Hastings
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Mutation Detection and Mutation Databases
cclm, 1998AbstractDetection of mutations in genes is vital throughout biology, however, this activity is time-consuming, expensive and requires a high degree of skill. This is unsatisfactory in a field which is increasing importance. Around 10–12 methods are commonly used with some predominating.
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