Results 141 to 150 of about 12,851 (183)
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Nature, 1991
The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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The detection and characterization of mutations in genes has become a major area of interest in many areas of biology. Such variation may account for speciation, tumour formation, drug resistance, as well as the more obvious nature of inherited disease.
R G, Cotton, A D, Malcolm
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Directional mutation pressure, mutator mutations, and dynamics of molecular evolution
Journal of Molecular Evolution, 1993Using a general form of the directional mutation theory, this paper analyzes the effect of mutations in mutator genes on the G+C content of DNA, the frequency of substitution mutations, and evolutionary changes (cumulative mutations) under various degrees of selective constraints.
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Dermatologic Clinics, 2010
A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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A mutation is an event that produces heritable changes in the DNA. There are many different types of mutations, including point mutations (changes that imply loss, duplication, or alterations of small DNA segments, often involving a single or a few nucleotides) and major DNA changes (loss, duplication, or rearrangements of entire genes or of gene ...
Daniele, Castiglia, Giovanna, Zambruno
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1978
With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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With the exception of repair mutagenesis, which was reviewed two years ago (RHEASE, 3), the investigations of the basic molecular mechanisms of mutation induction by chemical substances seem to have reached a certain saturation level. The different types of mutations like transitions, transversions, deletions, frameshift mutations, backbone breakage ...
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Journal of Theoretical Biology, 2003
A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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A traditional picture of evolutionary dynamics with constant fitness is that of genomes living in sequence space and adapting on fitness landscapes. Mutation rates are considered to be constant or externally regulated. If, however, we take into account that genomes also encode for enzymes that perform replication and error correction, then individual ...
Sasaki, Akira, Nowak, Martin A.
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Hospital Practice, 1985
The recent revolution in our understanding of biochemical genetics has radically altered the simple concepts that held sway “only yesterday.” Correspondingly, our appreciation of the complexity and variety of mutation has begun to provide a biochemical rationale for much of the clinical heterogeneity observed in many genetic diseases—e.g., the beta ...
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The recent revolution in our understanding of biochemical genetics has radically altered the simple concepts that held sway “only yesterday.” Correspondingly, our appreciation of the complexity and variety of mutation has begun to provide a biochemical rationale for much of the clinical heterogeneity observed in many genetic diseases—e.g., the beta ...
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Mutational analysis: new mutations
1995Abstract In the last few years the search for mutations and sequence polymorphisms has been dramatically accelerated by the use of PCR and subsequently by direct sequencing of PCR products (1, 2). In spite of these powerful new methods, direct sequencing is not always practicable in detecting mutations because they may be positioned ...
K Michaelides +4 more
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Mutational analysis: known mutations
1995Abstract This chapter attempts to illustrate the various PCR options that are available to detect specific mutations and/or polymorphisms in genomic DNA. In so doing, the relative merits and drawbacks of each technique are addressed in the respective sections. For some methods of PCR-assisted mutation detection covered in this chapter, a
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