Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas. [PDF]
World J Clin OncolMehta A, Bansal D, Tripathi R, Anoop V.
europepmc +1 more source
Editorial: CRISPR-Based Genome Editing in Translational Research-2nd Edition. [PDF]
CellsXu J, Zhang J, Yang D.
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Low Yield of Genetic Testing in Serrated Polyposis Syndrome. [PDF]
Clin Transl GastroenterolUpadhye I +4 more
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Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population. [PDF]
Int J Mol SciGoidescu IG +8 more
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MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells
Tumor Biology, 2013 MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung cancer development. However, the interaction between miRNAs and MMR genes and their regulatory effect on cell cycle remain poorly understood.
Zhaohui Gong
exaly +3 more sources
Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma [PDF]
Journal of Thoracic and Cardiovascular Surgery, 2005 Aberrant expression of mismatch repair genes, such as human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2), are common in some human cancers, and promoter methylation is believed to inactivate expression of hMLH1. We investigated whether promoter methylation is involved in loss of hMLH1 protein and whether aberrant expression of hMLH1 and ...
Ying-Jan Wang, Ho-Jui Tung
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MLH1 (human mutL homolog 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on MLH1 (human mutL homolog 1), with data on DNA, on the protein encoded, and where the gene is implicated.
E Domingo, S Jr Schwartz
exaly +2 more sources
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Abstract 86: Functional effects of MutL homolog 1 promoter polymorphism in prostate cancer
Cancer Research, 2016Abstract The mutL homolog (MLH1) gene protects the integrity of the genome by correcting erroneous insertions, deletions and mismatches that occur during DNA replication. Proper MLH1 expression is thus essential for the health of the cell and deficiency can result in mutation and genomic instability, which ultimately may lead to cancer ...
Shinichiro Fukuhara +11 more
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Abstract MutL homolog (MLH1) is one of several DNA mismatch repair genes of which defects can result in mutation and genomic instability, and ultimately may lead to cancer. Polymorphisms of MLH1 promoter have been shown to be a risk for several types of cancers and thus, we hypothesize that MLH1 promoter polymorphisms can be a risk ...
Yuichiro Tanaka +9 more
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MutL-Homolog 1 Expression and Risk of Incident, Sporadic Colorectal Adenoma: Search for Prospective Biomarkers of Risk for Colorectal Cancer [PDF]
Cancer Epidemiology Biomarkers and Prevention, 2009 AbstractTo characterize the expression of the mismatch repair gene MutL-homolog 1 (MLH1) in normal colorectal crypts in humans, and assess parameters of its expression as a potential biomarker of risk for colorectal neoplasms, we conducted a pilot, colonoscopy-based case-control study (51 cases, 154 controls) of incident, sporadic colorectal adenoma ...
Roberd M Bostick +2 more
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