Results 91 to 100 of about 27,474 (197)

Brain imaging data and summary data-based Mendelian randomization analysis reveal the impact of multiorgan aging on schizophrenia

Frontiers in Psychiatry
AimThe adverse health outcomes of schizophrenia (SZ) are largely driven by the high prevalence of other non-neurological diseases. In addition to accelerated brain aging, patients with SZ also exhibit signs of systemic aging.
Yan-Kun Han, Yan-Kun Han, Miao-Yan Liu, Ding-long Yang, Jia-Xin Xie, Xiao-Hui Wang, Dong-Bao Wang, Yun-Long Liang, Cui-Cui Wang, Long-Biao Cui, Long-Biao Cui, Long-Biao Cui, Yu-Jing Chen, Hai-Jun Zhang, Hai-Jun Zhang   +14 more
doaj   +1 more source

DNA Repair in Mammalian Cells: Mismatched repair: variations on a theme [PDF]

, 2018
.: Complementary base pairing underlies the genetic template function of the DNA double helix. Therefore, to assure faithful DNA transactions, cells must adhere to a strict application of the Watson-Crick base pairing principle.Yet, mispairing does arise
Kunz, C., Saito, Y., Schär, P.
core  

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G., Daum, J., Gross, M., Holinski-Feder, E., Kopp, R., Lohse, P., Muders, M., Mussack, T., Müller-Koch, Y., Schiemann, Uwe   +9 more
core   +1 more source

Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models [PDF]

, 2016
The authors thank Medical Research Scotland and the Scottish Funding Council. This work was su pported by Medical Research Scotland [FRG353 to V.A.S.]; the FP7 -­‐ Directorate -­‐ General for Research and Innovation of the European Commission [EU HEALTH -
Francis, Kyle, Harrison, David James, Kay, Charlene, Koussounadis, Antonis, Langdon, Simon, Smith, V Anne, Um, In Hwa   +6 more
core   +3 more sources

Malignant melanoma complicated with cataract and secondary glaucoma: A case report

Oncology Letters
Uveal melanoma is the most common intraocular malignant tumor in adults. For patients presenting with cataracts and glaucoma, it is recommended to assess whether an intraocular lesion is present as the primary cause.
Yu Wang, Qinqin Sun, Zhijian Li, Fei Leng, Xuelian Han, Qiqi Su, Sheng Su   +6 more
semanticscholar   +1 more source

OPTIMIZATION AND VALIDATION OF FOXP3, BRAFV600E AND MMR IMMUNOHISTOCHEMISTRY STAINING PROTOCOLS

Jurnal Teknologi
To ensure consistent and repeatable results, t Here, we described could enhance the IHC signals of the targeted antibodies. Mismatch Repair (MMR) proteins such as MutL homolog 1 (MLH1), Mut S homolog 2 (MSH2), Mut S homolog 6 (MSH6), and postmeiotic ...
R. I. Tsamiya, S. N. Mohd Nafi, Nur Asyilla Che Jalil, Anani Aila Mat Zin   +3 more
semanticscholar   +1 more source

Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells

Journal of Cancer, 2017
Background: Epidemiological studies suggest a protective role of estrogen against colon carcinogenesis; this effect appears to be dependent on mismatch repair (MMR) status. However, the underlying mechanism remains unclear.
P. Jin, De-zhi Wang, Chengxiu Lyu, Ya-ting Wang, Yu-qi He, J. Sheng, Xuhang Li   +6 more
semanticscholar   +1 more source

Clinicopathological Implications of Mismatch Repair Status in Endometrioid Endometrial Cancer in Duhok City

Cureus
Background: DNA mismatch repair (MMR) is a specialized system that corrects errors in DNA replication, namely, base substitution mismatches and minor insertion-deletion mismatches.
Ghorbat S Ali, Rafil T. Yaqo, Mahdi A Abdullah   +2 more
semanticscholar   +1 more source

Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum.

Oncology Letters, 2017
The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma (CRC). However, the mechanism triggered by the serrated pathway remains unclear.
Akihiro Tamoto, K. Yashima, K. Hosoda, Sohei Yamamoto, S. Kawata, Y. Ikebuchi, Kazuya Matsumoto, K. Kawaguchi, K. Harada, Y. Murawaki, H. Isomoto   +10 more
semanticscholar   +1 more source

Association between microsatellite instability status, clinicopathological features and mitochondrial DNA amplification in patients with colorectal cancer

Oncology Letters
The relationship between BRAF-V600E mutations, mitochondrial DNA amplification and microsatellite instability-high (MSI-H) in colorectal cancer (CRC) has yet to be fully elucidated.
Junmi Lu, Hong Tan, Tao Guo, Xi Chen, Zhongyi Tong   +4 more
semanticscholar   +1 more source