Results 81 to 90 of about 27,474 (197)

Algorithms of maximum likelihood data clustering with applications

, 2002
We address the problem of data clustering by introducing an unsupervised, parameter free approach based on maximum likelihood principle. Starting from the observation that data sets belonging to the same cluster share a common information, we construct ...
Alter, Blatt, Domany, Eisen, Getz, Getz, Giada, Gopikrishnan, Hartigan, Kirkpatrick, Kullmann, Lauritzen, Lorenzo Giada, Mantegna, Matteo Marsili, Metropolis, Spellman, Tamayo   +17 more
core   +1 more source

Drugging the Cancers Addicted to DNA Repair [PDF]

, 2017
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2).
Hromas, Robert, Jones, Dennie, Lee, Suk-Hee, Nickoloff, Jac A., Williamson, Elizabeth A.   +4 more
core   +1 more source

Established and Emerging Roles of Epigenetic Regulation in Diabetic Cardiomyopathy

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 6, September 2025.
ABSTRACT An increasing number of individuals are at high risk of type 2 diabetes (T2DM) and its cardiovascular (CV) complications, which challenges healthcare systems with an increased risk of developing CV diseases. Patients with T2DM exhibit a unique cardiac phenotype termed diabetic cardiomyopathy (DCM).
Adam Russell‐Hallinan, Narainrit Karuna, Frank Lezoualc'h, Giuseppe Matullo, Hana Baker, Monique Bernard, Yvan Devaux, Lina Badimon, Gemma Vilahur, Jennifer Rieusset, Geneviève A. Derumeaux, Chris J. Watson   +11 more
wiley   +1 more source

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

MedComm, Volume 6, Issue 9, September 2025.
Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng, Yu‐jia Zhao, Ce Chen, Feng Zhang   +3 more
wiley   +1 more source

DNA repair in the trinucleotide repeat disorders [PDF]

, 2017
Background Inherited diseases caused by unstable repeated DNA sequences are rare, but together represent a substantial cause of morbidity. Trinucleotide repeat disorders are severe, usually life-shortening, neurological disorders caused by nucleotide ...
Houlden, Henry, Jones, Lesley, Tabrizi, Sarah J.   +2 more
core   +2 more sources

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal‐Sensing Sensor Histidine Kinase ZraS

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 9, Page 1465-1480, September 2025.
ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra, Pranjal Mahanta, Shubhant Pandey, Rudresh Acharya   +3 more
wiley   +1 more source

Evaluation of MT1XT20 single quasi-monomorphic mononucleotide marker for characterizing microsatellite instability in persian lynch syndrome patients [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Shariatpanahi, Seyed Shervin., Zeinalian, Mehrdad.   +6 more
core  

The role of testosterone in colorectal carcinoma : pathomechanisms and open questions [PDF]

, 2016
Colorectal cancer (CRC) is the fourth commonest type of malignancy after breast, lung and prostate in the USA and accounts for approximately 49,190 deaths annually in USA alone. The 5-year survival rate of CRC has increased over the past decades, in part,
Pace, Nikolai Paul, Roshan, Mohsin H. K, Tambo, Amos   +2 more
core   +1 more source

AMPK Deficiency Increases DNA Methylation and Aggravates Colorectal Tumorigenesis in AOM/DSS Mice

Genes
The incidence of colorectal cancer (CRC) is closely linked to metabolic diseases. Accumulating evidence suggests the regulatory role of AMP-activated protein kinase (AMPK) in cancer metabolic reprogramming. In this study, wild-type and AMPK knockout mice
Qi Sun, Q. Tian, Alejandro Bravo Iniguez, Xiaofei Sun, Hui Zhang, J. Deavila, M. Du, Mei J. Zhu   +7 more
semanticscholar   +1 more source

Adenocarcinoma of the esophagus and gastroesophageal junction: The evolving treatment landscape for locally advanced and metastatic disease in the era of immune checkpoint inhibitors and biomarker‐driven therapeutics

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Laura V. M. Baum, Kimberly L. Johung, Joanna Gibson, Gabriel Cartagena, Daniel J. Boffa, Jill Lacy   +5 more
wiley   +1 more source