Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, Volume 158, Issue 2, Page 342-356, 15 January 2026.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Oncology Letters, 2017 The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma (CRC). However, the mechanism triggered by the serrated pathway remains unclear.
Akihiro Tamoto +10 more
semanticscholar +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens [PDF]
, 2017 MSH2 is a central component of the mismatch repair pathway that targets mismatches arising during DNA replication, homologous recombination (HR) and in response to genotoxic stresses.
Charlot, Florence +3 more
core
HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin +6 more
wiley +1 more source
Characterization of a large sex determination region in Salix purpurea L. (Salicaceae). [PDF]
, 2018 Dioecy has evolved numerous times in plants, but heteromorphic sex chromosomes are apparently rare. Sex determination has been studied in multiple Salix and Populus (Salicaceae) species, and P. trichocarpa has an XY sex determination system on chromosome
Carlson, Craig H +11 more
core
Evaluation of MT1XT20 single quasi-monomorphic mononucleotide marker for characterizing microsatellite instability in persian lynch syndrome patients [PDF]
, 2016 Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy.
Emami, Mohammad Hassan. +6 more
core
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)
Proceedings of the National Academy of Sciences of the United States of America, 2010 N. Valeri +12 more
semanticscholar +1 more source