Results 201 to 210 of about 17,684 (224)

Constructing Haloarchaeal MVA Pathway in Serratia marcescens for Synthesis of Ocimene

Biotechnology and Applied Biochemistry
ABSTRACT Ocimene, a valuable monoterpene with applications in agriculture, pharmaceuticals, and fragrances, is challenging to produce at high yields using traditional microbial platforms such as Escherichia coli and Saccharomyces cerevisiae
Songsong Yao, Di Liu, Long Wang, TaiPing Fan, Huaxiang Deng, Yujie Cai   +5 more
openaire   +1 more source

Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway

Plant Cell Reports, 2014
HMGS functions in phytosterol biosynthesis, development and stress responses. F-244 could specifically-inhibit HMGS in tobacco BY-2 cells and Brassica seedlings. An update on HMGS from higher plants is presented. 3-Hydroxy-3-methylglutaryl-coenzyme A synthase (HMGS) is the second enzyme in the mevalonate pathway of isoprenoid biosynthesis and catalyzes
Liao, P., Wang, H., Hemmerlin, A., Nagegowda, D.A., Bach, T.J., Wang, M., Chye, M.L.   +6 more
openaire   +5 more sources

Metabolic engineering of the MVA pathway for isoprenoid production in plants

2017
Invited talk - Session 3: Biotechnology and bioengineering (I) : OL5, p ...
Liao, P, Wang, H, Chen, X, Wang, M, Bach, T J, Chye, ML   +5 more
openaire   +1 more source

High-Efficiency Synthesis of β-Caryophyllene in Serratia marcescens via an Aeropyrum-Type MVA Pathway and Enzyme Engineering

Journal of Agricultural and Food Chemistry
β-caryophyllene is a high-value natural bicyclic sesquiterpenoid compound. In this study, a highly efficient biosynthetic system for β-caryophyllene was first constructed using the terpene-tolerant Serratia marcescens as the chassis. By introducing the energy-efficient Aeropyrum-type mevalonate (MVA) pathway and rationally designing the active pocket ...
Chengbo Xie, Di Liu, Linbo Gou, Shengfang Wu, Xiuwen Zhou, Tai-Ping Fan, Long Wang, Yujie Cai   +7 more
openaire   +2 more sources

Expression pattern of fifteen genes of non-mevalonate (MEP) and mevalonate (MVA) pathways in different tissues of endangered medicinal herb Picrorhiza kurroa with respect to picrosides content

Molecular Biology Reports, 2012
Picrorhiza kurroa, has become an endangered medicinal herb due to excessive utilization, therefore it necessitates the understanding of biology and molecular basis of major chemical constituents i.e. Picroside-I (P-I) and Picroside-II (P-II). Estimation of P-I and P-II in different tissues of P.
Saurabh, Pandit, Kirti, Shitiz, Hemant, Sood, Pradeep Kumar, Naik, Rajinder Singh, Chauhan   +4 more
openaire   +2 more sources

Constructing High-Yielding Serratia marcescens for (−)-α-Bisabolol Production Based on the Exogenous Haloarchaeal MVA Pathway and Endogenous Molecular Chaperones

Journal of Agricultural and Food Chemistry
(-)-α-Bisabolol exhibits analgesic, anti-inflammatory, and skin-soothing properties and is widely applied in the cosmetic and pharmaceutical industries. The use of plant essential oil distillation or chemical synthesis to produce (-)-α-bisabolol is both inefficient and unsustainable.
Yao Lu, Di Liu, Long Wang, Yongai Ma, Tai-Ping Fan, Huaxiang Deng, Yujie Cai   +6 more
openaire   +2 more sources

[Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2010
Two distinct routes (classical mevalonate pathway and a novel mevalonate-independent pathway) are utilized by plants for the biosynthesis of isopentenyl diphosphate, the universal precursor of isoprenoids (Fig. 1). Present researches indicated that taxol was synthesized mainly via non-mevalonate pathway, but not genetic evidence was showed.
Qing-Ping, Zheng, Long-Jiang, Yu, Zhi, Liu, Mo-Yi, Li, Fu, Xiang, Qin, Yang   +5 more
openaire   +1 more source

The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

Molecular Cell, 2021
Shanshan Zhong, Hanling Wang, Xuege Wang   +2 more
exaly  

MVA-infected dendritic cells present CD4⁺ T-cell epitopes by endogenous MHC class II presentation pathways.

2015
CD4+ T-lymphocytes play a central role in the immune system and mediate their function after recognition of their respective antigens presented on MHCII molecules on antigen presenting cells (APCs). Conventionally, phagocytosed antigens are loaded on MHCII for stimulation of CD4+ T-cells.
Thiele, F., Tao, S., Zhang, Y., Muschaweckh, A., Zollmann, T., Protzer, U., Abele, R., Drexler, I.   +7 more
openaire   +1 more source

Immunogenicity of High-Dose MVA-Based MERS Vaccine Candidate in Mice and Camels

Vaccines, 2022
Naif Khalaf Alharbi, Abdulrahman Almasoud, Esam I Azhar   +2 more
exaly