Results 61 to 70 of about 28,626 (196)

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Outcome measures in long COVID clinical trials: a review

Frontiers in Public Health
BackgroundLong COVID is a multisystem disease that affects approximately 10% of people after a SARS-CoV-2 infection. In the absence of curative treatment, high-quality clinical treatment trials are urgently needed for long COVID.
Femke C. C. van Rhijn-Brouwer, Chloé de Canson, Joanneke E. L. VanDerNagel, Xandra Westerhuis, Susanne Y. Young, Sander M. J. van Kuijk, Laura V. de Vries, Jon-Ruben van Rhijn, Merel Hellemons   +8 more
doaj   +1 more source

Severe Pediatric MOGAD‐Associated ADEM With Persistent Neurological Morbidity and Later‐Onset Epilepsy of Uncertain Etiology: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This report describes a 7‐year‐old boy with MOGAD presenting as severe ADEM with fever, encephalopathy, seizures, markedly elevated intracranial pressure, diffuse multifocal MRI abnormalities, and serum MOG‐IgG positivity. He required intravenous corticosteroids, plasma exchange, IVIG, and tocilizumab, followed by rehabilitation and ...
Desiree‐Anne Ramsaran, Garrett Gianneschi, Janet Elgallab   +2 more
wiley   +1 more source

Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study

Journal of Translational Medicine
Background Light is a major environmental factor regulating circadian rhythms, sleep- wake cycles, and mood-related behaviors. Patients with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience circadian disruption and poor sleep ...
Trinitat Cambras, Joan Carles Domingo, Ramon Sanmartín-Sentañes, José Alegre-Martín, Jesús Castro-Marrero   +4 more
doaj   +1 more source

JTM advances in uncharted territories: diseases and disorders of unknown etiology

Journal of Translational Medicine, 2017
We are delighted to announce a new section in the Journal of Translational Medicine, ‘Illnesses of Unknown Etiology’. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and ...
Monica C. Panelli
doaj   +1 more source

Myalgic Encephalomyelitis: Symptoms and Biomarkers [PDF]

Current Neuropharmacology, 2015
Myalgic Encephalomyelitis (ME) continues to cause significant morbidity worldwide with an estimated one million cases in the United States. Hurdles to establishing consensus to achieve accurate evaluation of patients with ME continue, fueled by poor agreement about case definitions, slow progress in development of standardized diagnostic approaches ...
Jason, Leonard A., Zinn, Marcie L., Zinn, Mark A.   +2 more
openaire   +2 more sources

Cochlear Implantation in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) is a neuroimmunologic demyelinating disorder that may present with central or peripheral sensorineural hearing loss (SNHL). This case describes a 43‐year‐old female with MOGAD and profound right‐sided SNHL who did not improve with neuroimmunologic therapy.
Jacob Mabey, Hannah Dunn, Justin Cottrell   +2 more
wiley   +1 more source

A patient's journey with myalgic encephalomyelitis [PDF]

BMJ, 2005
Myalgic encephalomyelitis (ME) presents patients and their general practitioners with the challenge of managing a life shaped by chronic debilitating illness, pain, and uncertainty. The notion that body limitations resulting from illness must be recognised is shown in the literature on chronic illness, but at the same time it is necessary to understand
Bie Nio, Ong, Daphne, Evans, Andrew, Bartlam   +2 more
openaire   +2 more sources

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source

Does Current United Kingdom Childhood Cancer Research Address the James Lind Alliance Children's Cancer Priority Setting Partnership Priorities? A Grant Mapping Study

Health Expectations, Volume 29, Issue 5, October 2026.
ABSTRACT Introduction The James Lind Alliance Children's Cancer Priority Setting Partnership identified 23 key research topics, as defined by children, survivors, families, carers, and professionals. Funders have expressed commitment to ensuring all priorities are addressed.
Alison Bish, Faith Gibson, Alexandra Brownsdon, Julia Chisholm, Jenny Harris, Rachel Hollis, Bob Phillips, Susie Aldiss   +7 more
wiley   +1 more source