Results 101 to 110 of about 77,428 (296)

When more sugar is better—a GPI side chain modification results in a less virulent phenotype during a protozoan infection

mBio
The assembly and function of side chain modifications of glycosylphosphatidylinositol (GPI) units (anchors or free forms) are poorly defined. In a recent study, two enzymes, PIGJ and PIGE, of the protozoan parasite Toxoplasma gondii were identified and ...
Frank Seeber
doaj   +1 more source

New Structure Activity Relationship Insight into the Role of the C‐3 Extension on Rifamycin Antimycobacterial Activity

ChemMedChem, EarlyView.
Rifamycin analogues with variably functionalized C‐3 extensions provide new insight into the role of this region for MTb inhibitory activity. In addition to potentially optimizing target engagement, this region can also be used to modulate physicochemical properties, an important consideration for optimizing antimycobacterial activity.
Clinton G. L. Veale, Ewelina Smolarz, Aleksandra Leśniewska, Krystian Pyta, Piotr Przybylski   +4 more
wiley   +1 more source

Mycobacteria in Fish Liver Oils [PDF]

, 1955
Paul S. Prickett, W. Wiehle
openalex   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Detection of Mtb and NTM: preclinical validation of a new asymmetric PCR-binary deoxyribozyme sensor assay

Microbiology Spectrum
Tuberculosis (TB) and infectious diseases caused by non-tuberculous mycobacteria (NTM) are global concerns. The development of a rapid and accurate diagnostic method, capable of detecting and identifying different mycobacteria species, is crucial.
Yasmin Castillos das Neves, Ana Julia Reis, Marcos Alaniz Rodrigues, Erica Chimara, Maria Cristina da Silva Lourenço, Jacques Fountain, Ivy Bastos Ramis, Andrea von Groll, Yulia Gerasimova, Kyle H. Rohde, Pedro Eduardo Almeida da Silva   +10 more
doaj   +1 more source

Synthesis of Bioorthogonal Mycolic Acids: Chemoselective Reduction of β‐Ketoesters Containing an Alkyne Using the Noyori Catalyst

European Journal of Organic Chemistry, EarlyView.
Bioorthogonal mycolic acids that are suitable probes for the study of the cell envelope of mycobacteria are synthesized by Noyori reduction of β‐ketoesters featuring a protected terminal alkyne. The triisopropylsilyl group is found to be very efficient in preventing the reduction of the alkyne.
Paulin Rollando, Emilie Lesur, Dominique Urban, Gilles Doisneau, Dominique Guianvarc'h, Yann Bourdreux   +5 more
wiley   +1 more source

Mycobacteria and their world

International Journal of Mycobacteriology, 2012
Cynthia Ann Stanford, John Lawson Stanford   +1 more
openaire   +4 more sources

Destruction of Various Kinds of Mycobacteria in Milk by Pasteurization [PDF]

, 1965
Rube Harrington, Alfred G. Karlson
openalex   +1 more source

Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review

Food Frontiers, EarlyView.
Polysaccharides derived from medicine‐food plants restore intestinal barrier integrity and microbiota balance while modulating short‐chain fatty acid levels. These modifications significantly alleviate diabetes and its complications, including nephropathy, retinopathy, cardiovascular disease, and neuropathy.
Yi Long, Wanglong Yu, Pingping Yang, Minxuan Xu, Jitao Ling, Yuting Wu, Xiao Liu, Liu Ouyang, Yan Xiong, Jianping Liu, Yiming Gan, Jing Zhang, Peng Yu, Deju Zhang   +13 more
wiley   +1 more source

In Vitro Effect of Rifampin on Mycobacteria [PDF]

, 1969
Víctor Lorian, Maxwell Finland
openalex   +1 more source