Results 81 to 90 of about 77,428 (296)

EVIDENCE SUGGESTING THAT THE GRANULES OF MYCOBACTERIA ARE MITOCHONDRIA [PDF]

, 1951
Stuart Mudd, Loren C. Winterscheid, Edward D. DeLamater, Howard J. Henderson   +3 more
openalex   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

MEASUREMENT OF THE HYDROGEN TRANSFER CAPACITY OF MYCOBACTERIA [PDF]

, 1951
John H. Hanks
openalex   +1 more source

Bioprospecting of Labdane‐Type Diterpenes From Austroeupatorium laetevirens: Molecular Networking, Structural Elucidation, and Biological Activity Evaluation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Labdane‐type diterpenes are the main specialized metabolites in the Austroeupatorium genus, known for diverse biological activities. This study employed molecular networking to facilitate the identification of labdanes in Austroeupatorium laetevirens, alongside isolation, structural elucidation, and evaluation of anti‐Mycobacterium ...
Francielli A. P. Valeze, Maria Eduarda V. de Souza, Beatriz P. Moreno, Bianca D. B. Sahm, Andressa L. Ieque, Cleverton S. Fernandes, Regiane B. L. Scodro, Leticia V. Costa‐Lotufo, Marta R. B. do Carmo, Andrea N. L. Batista, João M. Batista Junior, Ernani A. Basso, Maria H. Sarragiotto, Debora C. Baldoqui   +13 more
wiley   +1 more source

A Quantitative Analysis of the Resistance of Mycobacteria to Streptomycin [PDF]

, 1948
Dirán Yegian, Robert J. Vanderlinde
openalex   +1 more source

Hydrogen‐Deuterium Exchange Defines Ligand‐Induced Conformational Changes to the Class III Biotin Protein Ligase from Saccharomyces cerevisiae

ChemBioChem, EarlyView.
Hydrogen‐deuterium exchange mass spectrometry validated AlphaFold structural prediction of the class III biotin protein ligase (BPL) from Saccharomyces cerevisiae, and revealed a structured domain in the N‐terminal extension characteristic to this class of BPL.
Louise M. Sternicki, Tara L. Pukala, Kamila J. Pacholarz, Perdita Barran, Grant W. Booker, Steven W. Polyak, Kate L. Wegener   +6 more
wiley   +1 more source

A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides

eLife
The Nix-TB clinical trial evaluated a new 6 month regimen containing three oral drugs; bedaquiline (B), pretomanid (Pa), and linezolid (L) (BPaL regimen) for the treatment of tuberculosis (TB).
Malik Zohaib Ali, Taru S Dutt, Amy MacNeill, Amanda Walz, Camron Pearce, Ha Lam, Jamie S Philp, Johnathan Patterson, Marcela Henao-Tamayo, Richard Lee, Jiuyu Liu, Gregory T Robertson, Anthony J Hickey, Bernd Meibohm, Mercedes Gonzalez Juarrero   +14 more
doaj   +1 more source

EXPERIENCE OF USING THE MINIMUM INHIBITORY CONCENTRATION METHOD ON LIQUID NUTRITIONAL MEDIA FOR DRUG SUSCEPTIBILITY TESTING OF NON-TUBERCULOUS MYCOBACTERIA

Туберкулез и болезни лёгких, 2017
Goal of the study: analysis of drug resistance of certain species of non-tuberculous mycobacteria through testing by minimum inhibitory concentrations on the fluid nutritional media.Materials and method: drug resistance of non-tuberculous mycobacteria ...
O. I. Alkhovik, T. I. Petrenko
doaj   +1 more source

Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C‐Terminus of α‐Synuclein Fibrils

ChemBioChem, EarlyView.
Binding studies of α‐synuclein (αS) fibril ligands using photo‐crosslinking mass spectrometry and Förster resonance energy transfer show that the multiple system atrophy (MSA)‐selective lead, HY‐215, interacts with the αS C‐terminus, unlike Parkinson's disease (PD)‐selective lead, M503. Thus, often‐ignored interactions with the disordered regions of αS
Kyle D. Shaffer, Ryann M. Perez, Marshall G. Lougee, Vinayak V. Pagar, Hee Jong Kim, Ho Young Kim, Benjamin A. Garcia, Robert H. Mach, E. James Petersson   +8 more
wiley   +1 more source

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

ChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source