Results 81 to 90 of about 165,721 (325)

What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections? [PDF]

, 2017
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung.
Adcock, IM, Garssen, J, Kazempour Dizagie, M, Mirsaeidi, M, Moloudizargari, M, Mortaz, E, Movassaghi, M, Varahram, M   +7 more
core  

Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures

Nature Communications, 2017
The mycobacteria RNA polymerase (RNAP) is a target for antimicrobials against tuberculosis, motivating structure/function studies. Here we report a 3.2 Å-resolution crystal structure of a Mycobacterium smegmatis (Msm) open promoter complex (RPo), along ...
Elizabeth A. Hubin, M. Lilic, S. Darst, E. Campbell   +3 more
semanticscholar   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Leptomeningitis in a person with radiologically isolated syndrome and latent tuberculosis. A case report with implications for clinical research [PDF]

, 2018
A 39-year-old man, followed with serial MRI of CNS for a radiologically isolate syndrome (RIS, a recently described condition considered a subclinical form of MS), was hospitalized for the occurrence of a leptomeningitis. Routine blood tests and contrast
Bozzao, Alessandro, Chiara Buscarinu, Maria, Ferraldeschi, Michela, Fornasiero, Arianna, Ristori, Giovanni, Romano, Andrea, Romano, Silvia, Salvetti, Marco, Teggi, Antonella   +8 more
core   +1 more source

Mycobacteria employ two different mechanisms to cross the blood–brain barrier

Cellular Microbiology, 2018
Central nervous system (CNS) infection by Mycobacterium tuberculosis is one of the most devastating complications of tuberculosis, in particular in early childhood. In order to induce CNS infection, M.
L. V. Leeuwen, M. Boot, C. Kuijl, Daisy I. Picavet, G. Stempvoort, S. Pol, Helga E. Vries, Nicole N. Wel, M. Kuip, A. M. Furth, A. M. Sar, W. Bitter   +11 more
semanticscholar   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Evaluation of Xpert® MTB/RIF and ustar easyNAT™ TB IAD for diagnosis of tuberculous lymphadenitis of children in Tanzania : a prospective descriptive study [PDF]

, 2016
Fine needle aspiration biopsy has become a standard approach for diagnosis of peripheral tuberculous lymphadenitis. The aim of this study was to compare the performance of Xpert MTB/RIF and Ustar EasyNAT TB IAD nucleic acid amplification assays, against ...
AT Cruz, CA Wright, CA Wright, CA Wright, CC Anunobi, CC Boehme, CJL Murray, CM Denkinger, CM Denkinger, CM Perez-Velez, D Hillemann, E Penz, Edward Masika, ES Cibas, F Ardito, FA Mhimbira, Hans-Peter Beck, Hassan Chande, J Ayugi, J Cohen, JA Seddon, JB Reitsma, Klaus Reither, L Coetzee, Levan Jugheli, M Pai, Maira Bholla, Mohamed Sasamalo, Neema Kapalata, PJ Dodd, R Fang, RR Kazwala, S Chakravorty, SGM Mfinanga, SH Siddiqi, SM Newton, Tracy R. Glass, Ustar Biotechnologies, World Health Organization, X Ou   +39 more
core   +3 more sources

Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations

Frontiers in Microbiology, 2018
Model bacteria, such as E. coli and B. subtilis, tightly regulate cell cycle progression to achieve consistent cell size distributions and replication dynamics. Many of the hallmark features of these model bacteria, including lateral cell wall elongation
Michelle M Logsdon, B. Aldridge
semanticscholar   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Draft Genome Sequence of Mycobacterium obuense Strain UC1, Isolated from Patient Sputum. [PDF]

, 2015
We report the draft genome sequence of Mycobacterium obuense strain UC1 from a patient sputum sample. This is the first draft genome sequence of Mycobacterium obuense, a rapidly growing scotochromogenic ...
Chiu, Charles Y, Cunningham, Gail, Greninger, Alexander L, Hsu, Elaine D, Miller, Steve, Yu, Joanna M   +5 more
core   +2 more sources