Results 141 to 150 of about 648,089 (387)
Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols
ChemBioChem, EarlyView.Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen +4 more
wiley +1 more source
ChemBioChem, EarlyView.The study characterizes interactions between DnaB helicase and DnaG primase in Mycobacterium tuberculosis using small‐angle X‐ray scattering, surface plasmon resonance, and cross‐linking. The findings reveal that DnaG forms dimers in solution, which are destabilized upon DnaB binding.
Dayan A, Ilic S, Akabayov B
wiley +1 more source
ChemBioChem, Accepted Article.Non‐muscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette‐Guérin (BCG) immunotherapy as the gold standard for high‐risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, we developed a trehalose‐based conjugation strategy, tethering
Michael Grimmeisen +10 more
wiley +1 more source
Congenital tuberculosis: a case report
Brazilian Journal of Infectious DiseasesCongenital tubercolosis is an unusual and severe clinical pattern of tuberculosis presentation of Mycobacterium tuberculosis infection. Furthermore, it usually has a difficult treatment.
Liana Consuelo Santana Vilarinho
doaj +1 more source
Non-tuberculous mycobacteria: baseline data from three sites in Papua New Guinea, 2010–2012
Western Pacific Surveillance and Response, 2015 Objective: To determine the proportion of non-tuberculous mycobacteria (NTM) in samples of pulmonary tuberculosis (TB) cases from Papua New Guinea who were diagnosed using acid-fast microscopy.
Serej Ley +7 more
doaj +1 more source
Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy [PDF]
, 2018 Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic.
Colombo, Maria Isabel +2 more
core
In situ PCR for Mycobacterium tuberculosis in endoscopic mucosal biopsy specimens of intestinal tuberculosis and Crohn disease [PDF]
, 2008 Tuberculosis and Crohn disease are granulomatous disorders affecting the intestinal tract with similar clinical manifestations and pathologic features.
Donoghue, HD +3 more
core +1 more source
International Journal of Systematic and Evolutionary Microbiology, 2016 The taxonomic position of members of the Mycobacterium abscessus complex has been the subject of intensive investigation and, in some aspects confusion, in recent years as a result of varying approaches to genetic data interpretation.
E. Tortoli +18 more
semanticscholar +1 more source
ChemCatChem, EarlyView.An enzyme that has been identified and characterized as capable of hydrolyzing paclitaxel (Taxol), a key anticancer drug derived from Pacific yew (Taxus brevifolia) has been identified. Molecular docking (MD) simulations map the catalytic triad and critical residues that drive substrate‐enzyme interactions. The findings indicate the catalytic potential
Jinfen Su +3 more
wiley +1 more source
Draft Genome Sequence of Mycobacterium heckeshornense Strain RLE. [PDF]
, 2015 We report here the draft genome sequence of Mycobacterium heckeshornense strain RLE isolated from a sputum sample from a patient with shortness of breath.
Chiu, Charles Y +3 more
core +1 more source