Sensitivity of Mycobacterium leprae to Telacebec [PDF]
Emerging Infectious Diseases, 2022 The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis.
Ramanuj Lahiri +3 more
doaj +7 more sources
Pathogenicity and virulence of Mycobacterium leprae. [PDF]
Virulence, 2022 Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate intracellular organism, and over 200,000 new cases occur every year. M.
Sugawara-Mikami M +6 more
europepmc +5 more sources
Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy [PDF]
Frontiers in Microbiology, 2022 The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected ...
Natasha Cabral +9 more
doaj +3 more sources
Mycobacterium leprae genomes from naturally infected nonhuman primates. [PDF]
PLoS Neglected Tropical Diseases, 2018 Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M.
Tanvi P Honap +9 more
doaj +2 more sources
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
Nature Communications, 2018 Leprosy is caused by the yet-uncultured pathogen Mycobacterium leprae. Here, Benjak et al. obtain M. leprae genome sequences from DNA extracted from patients' skin biopsies and, by analysing 154 genomes from 25 countries, provide insight into the ...
Andrej Benjak +42 more
doaj +2 more sources
A Zebrafish Model of Mycobacterium leprae Granulomatous Infection. [PDF]
bioRxiv, 2017 Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at approximately 30°C, so we sought to model granulomatous disease in
Cameron, James +2 more
core +3 more sources
Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil [PDF]
Brazilian Journal of Infectious DiseasesLeprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study
Beatriz Silva Nogueira +4 more
doaj +2 more sources
Frontiers in Microbiology, 2018 Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of ...
Diana Machado +13 more
doaj +2 more sources
Mycobacterium leprae Activates Toll-Like Receptor-4 Signaling and Expression on Macrophages Depending on Previous Bacillus Calmette-Guerin Vaccination. [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 Toll-like receptor (TLR)-1 and TLR2 have been shown to be receptors for Mycobacterium leprae (M. leprae), yet it is unclear whether M. leprae can signal through alternative TLRs.
Andersen +56 more
core +3 more sources
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2023 Background: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms ...
Amanda Juliane Finardi +6 more
doaj +2 more sources