Results 1 to 10 of about 174,365 (247)
Sensitivity of Mycobacterium leprae to Telacebec [PDF]
Emerging Infectious Diseases, 2022 The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis.
Ramanuj Lahiri +3 more
doaj +5 more sources
Definitions, 2020 The finding that in patients with lepromatous leprosy much larger numbers of bacilli are released from the nasal mucosa and from the milk ducts of lactating mothers as compared with those present on the surface of the skin, suggests the possibility of ...
Diana L. Williams, Thomas P. Gillis
semanticscholar +3 more sources
Pathogenicity and virulence of Mycobacterium leprae. [PDF]
Virulence, 2022 Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate intracellular organism, and over 200,000 new cases occur every year. M.
Sugawara-Mikami M +6 more
europepmc +2 more sources
Mycobacterium leprae genomes from naturally infected nonhuman primates. [PDF]
PLoS Neglected Tropical Diseases, 2018 Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M.
Tanvi P Honap +9 more
doaj +2 more sources
Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
Nature Communications, 2018 Leprosy is caused by the yet-uncultured pathogen Mycobacterium leprae. Here, Benjak et al. obtain M. leprae genome sequences from DNA extracted from patients' skin biopsies and, by analysing 154 genomes from 25 countries, provide insight into the ...
Andrej Benjak +42 more
doaj +2 more sources
Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy
Frontiers in Microbiology, 2022 The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected ...
Natasha Cabral +9 more
doaj +2 more sources
Frontiers in Microbiology, 2018 Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of ...
Diana Machado +13 more
doaj +2 more sources
Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus [PDF]
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2020 Mineralized dental plaque (calculus) has proven to be an excellent source of ancient biomolecules. Here we present a Mycobacterium leprae genome (6.6-fold), the causative agent of leprosy, recovered via shotgun sequencing of sixteenth-century human ...
A. Fotakis +12 more
semanticscholar +2 more sources
Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil [PDF]
Brazilian Journal of Infectious DiseasesLeprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study
Beatriz Silva Nogueira +4 more
doaj +2 more sources
Intracellular
mBio, 2019 New approaches are needed to control leprosy, but understanding of the biology of the causative agent Mycobacterium leprae remains rudimentary, principally because the pathogen cannot be grown in axenic culture.
Khushboo Borah +7 more
doaj +2 more sources