Sensitivity of Mycobacterium leprae to Telacebec [PDF]
Emerging Infectious Diseases, 2022 The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis.
Ramanuj Lahiri +3 more
doaj +7 more sources
Pathogenicity and virulence of Mycobacterium leprae. [PDF]
Virulence, 2022 Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes histiocytes (skin macrophages) and Schwann cells in the peripheral nerves.
Sugawara-Mikami M +6 more
europepmc +4 more sources
Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae. [PDF]
Front Microbiol, 2021 In 1926, a mycobacterial skin disease was observed in water buffaloes by researchers in Indonesia. The disease was designated as skin tuberculosis, though it was hypothesized that it might be a form of leprosy or a leprosy-like disease. In a follow-up study (Ph.D.
Faber WR, Menke H, Rutten V, Pieters T.
europepmc +8 more sources
<i>Mycobacterium leprae</i> Slide Positivity at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia: Seven Years Retrospective Study. [PDF]
Health Sci RepABSTRACT Background Mycobacterium leprae is the cause of leprosy, a disease whose severity worsens over time. It affects the nerves of the extremities, the integumentary systems, the linings of appendages like the nose, and the upper respiratory tract. This study aimed to determine the of M.
Erkihun M +11 more
europepmc +2 more sources
Mycobacterium leprae Infection in Ticks and Tick-Derived Cells [PDF]
Frontiers in Microbiology, 2021 Leprosy is a zoonosis in the southern United States involving humans and wild armadillos. The majority of patients presenting with zoonotic strains of Mycobacterium leprae note extensive outdoor activity but only rarely report any history of direct ...
Natthida Tongluan +12 more
doaj +2 more sources
Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil [PDF]
Brazilian Journal of Infectious DiseasesLeprosy is a chronic infectious disease caused by the bacilli Mycobacterium leprae and Mycobacterium lepromatosis. In addition to humans, animals such as nine-banded armadillos and red squirrels are species naturally infected. The objective of this study
Beatriz Silva Nogueira +4 more
doaj +2 more sources
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2023 Background: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms ...
Amanda Juliane Finardi +6 more
doaj +2 more sources
Fecal Excretion of Mycobacterium leprae, Burkina Faso [PDF]
Emerging Infectious Diseases, 2021 Mycobacterium leprae was detected by optical microscopy, fluorescent in situ hybridization, and molecular detection in feces collected for the diagnosis of Entamoeba coli enteritis in a leprosy patient in Burkina Faso.
Anselme Millogo +5 more
doaj +2 more sources
Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy [PDF]
Frontiers in Microbiology, 2022 The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected ...
Natasha Cabral +9 more
doaj +2 more sources
Mycobacterium leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico [PDF]
Emerging Infectious Diseases, 2022 Nine-banded armadillos (Dasypus novemcinctus) are naturally infected with Mycobacterium leprae and are implicated in the zoonotic transmission of leprosy in the United States. In Mexico, the existence of such a reservoir remains to be characterized.
Lucio Vera-Cabrera +13 more
doaj +2 more sources